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LGR5/GPR49 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1582356

MBS1582356 is an antibody targeting LGR5/GPR49. Also known as Anti-Human LGR5/GPR49 Antibody (SAA0507), APC. Reactive in Human. Host: Mouse. More details

$415 / 50 Tests +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LGR5/GPR49, Monoclonal Antibody
Full Product Name
Anti-Human LGR5/GPR49 Antibody (SAA0507), APC
Product Gene Name
Product Synonym Names
G-protein coupled receptor 49; G-protein coupled receptor HG38; LGR5; GPR67; GPR49; G-protein coupled receptor 67; Leucine-rich repeat-containing G-protein coupled receptor 5
Clonality
Monoclonal
Isotype
IgG2a, kappa
Clone Number
SAA0507
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Concentration
0.5mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for 12 months. Protect from light. Do not freeze.
Molecular Weight
99998 MW
OMIM
AF062006 mRNA
3D Structure
ModBase 3D Structure for O75473
Conjugation
APC
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-LGR5/GPR49 antibody
Flow Cytometry (FC/FACS/FCM), Western Blot (WB)

Other Notes

Small volumes of anti-LGR5/GPR49 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LGR5/GPR49. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
leucine-rich repeat-containing G-protein coupled receptor 5 isoform 2
NCBI Official Synonym Full Names
leucine rich repeat containing G protein-coupled receptor 5
NCBI Official Symbol
LGR5
NCBI Official Synonym Symbols
FEX; HG38; GPR49; GPR67; GRP49
UniProt Protein Name
Leucine-rich repeat-containing G-protein coupled receptor 5
UniProt Synonym Protein Names
G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
UniProt Gene Name
LGR5
UniProt Synonym Gene Names
GPR49; GPR67
NCBI Protein Information
leucine-rich repeat-containing G-protein coupled receptor 5

NCBI Summary for LGR5/GPR49

The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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UniProt Comments for LGR5/GPR49

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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