Anti-LGR4 Monoclonal Antibody – Cat# MBS1585060

LGR4 Antibody – Monoclonal

Name: LGR4 Antibody; Monoclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1585060
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1585060

MBS1585060 is an antibody targeting LGR4. Also known as Anti-Human LGR4 Antibody (SAA0107), PE. Reactive in Human. More details

$415 / 50 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LGR4, Monoclonal Antibody

Full Product Name

Anti-Human LGR4 Antibody (SAA0107), PE

Product Gene Name

anti-LGR4 antibody

Product Synonym Names

GPR48; Leucine-rich repeat-containing G-protein coupled receptor 4; LGR4; G-protein coupled receptor 48; RHJ50601

Clonality

Monoclonal

Isotype

IgG1

Clone Number

SAA0107

Species Reactivity

Human

Form/Format

Liquid; 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Concentration

0.5mg/ml (lot specific)

Preparation and Storage

Store at 4 degree C for 12 months. Protect from light. Do not freeze.

Molecular Weight

104,475 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (27387508..27494334, complement). Location: 11p14-p13

OMIM

606666

3D Structure

ModBase 3D Structure for Q9BXB1

Conjugation

Host Species

Human

Product Categories/Family for anti-LGR4 antibody

Super-Affinity Antibodies; Flow Cytometry Antibodies

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-LGR4 antibody

ELISA (EIA), Flow Cytometry (FC/FACS/FCM), Western Blot (WB)

Other Notes

Small volumes of anti-LGR4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LGR4. It may not necessarily be applicable to this product.

NCBI GI #

157694513

NCBI GeneID

55366

NCBI Accession #

NP_060960.2

UniProt Primary Accession #

Q9BXB1

UniProt Secondary Accession #

Q9NYD1; A6NCH3

UniProt Related Accession #

Q9BXB1

GenBank Nucleotide #

NM_018490.2

NCBI Official Full Name

leucine-rich repeat-containing G-protein coupled receptor 4

NCBI Official Synonym Full Names

leucine-rich repeat containing G protein-coupled receptor 4

NCBI Official Symbol

LGR4

NCBI Official Synonym Symbols

GPR48

UniProt Protein Name

Leucine-rich repeat-containing G-protein coupled receptor 4

UniProt Synonym Protein Names

G-protein coupled receptor 48

Protein Family

Leucine-rich repeat-containing G-protein coupled receptor

UniProt Gene Name

LGR4

UniProt Synonym Gene Names

GPR48

UniProt Entry Name

LGR4_HUMAN

NCBI Protein Information

leucine-rich repeat-containing G-protein coupled receptor 4; G protein-coupled receptor 48

NCBI Summary for LGR4

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008]

UniProt Comments for LGR4

LGR4: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Plays an essential role during homeostasis of the adult mouse intestine.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p14-p13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: osteoblast differentiation; G-protein coupled receptor protein signaling pathway; epithelial cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of cytokine secretion; male genitalia development; negative regulation of toll-like receptor signaling pathway; innate immune response; spermatogenesis; circadian regulation of gene expression; bone remodeling; negative regulation of transcription, DNA-dependent; bone mineralization

Disease: Bone Mineral Density Quantitative Trait Locus 17

Research Articles on LGR4

1. R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-LGR4 antibody

Disease Name	Pubmed Publications
Infertility, Female Antibodies	>2 publications with LGR4 and Infertility, Female
Neoplasms, Experimental Antibodies	>2 publications with LGR4 and Neoplasms, Experimental
Alopecia Antibodies	>1 publications with LGR4 and Alopecia
Anemia Antibodies	>1 publications with LGR4 and Anemia
Gonadal Disorders Antibodies	>1 publications with LGR4 and Gonadal Disorders
Disease Models, Animal Antibodies	>1 publications with LGR4 and Disease Models, Animal
Kidney Diseases Antibodies	>1 publications with LGR4 and Kidney Diseases
Inflammation Antibodies	>1 publications with LGR4 and Inflammation

Organs/Tissues associated with anti-LGR4 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>8 publications with LGR4 and Kidney
Liver Antibodies	>6 publications with LGR4 and Liver
Intestine Antibodies	>6 publications with LGR4 and Intestine
Testis Antibodies	>6 publications with LGR4 and Testis
Brain Antibodies	>5 publications with LGR4 and Brain
Embryonic Tissue Antibodies	>4 publications with LGR4 and Embryonic Tissue
Eye Antibodies	>4 publications with LGR4 and Eye
Skin Antibodies	>4 publications with LGR4 and Skin
Ovary Antibodies	>4 publications with LGR4 and Ovary
Lung Antibodies	>3 publications with LGR4 and Lung