CD243 Antibody – Rat Monoclonal

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]

ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.

Protein type: Membrane protein, integral; Transporter, ABC family; EC 3.6.3.44; Hydrolase; Cell adhesion; Membrane protein, multi-pass; Transporter

Cellular Component: intercellular canaliculus; cell surface; membrane; apical part of cell; plasma membrane; integral to membrane

Molecular Function: hydrolase activity; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; nucleotide binding; ATPase activity, coupled; xenobiotic-transporting ATPase activity; ATP binding

Biological Process: daunorubicin transport; hormone transport; drug transport; transport; drug export; xenobiotic transport; multidrug transport; G2/M transition of mitotic cell cycle; transmembrane transport