NOTCH2/3 Antibody – Rat Monoclonal

Notch 2: a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. Affects the implementation of differentiation, proliferation and apoptotic programs. Cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. This protein functions as a receptor for the membrane bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Cellular Component: cell surface; membrane; cell; integral to plasma membrane; plasma membrane; integral to membrane; nucleus; receptor complex; cilium

Molecular Function: NF-kappaB binding; protein binding; enzyme binding; calcium ion binding

Biological Process: wound healing; positive regulation of osteoclast differentiation; positive regulation of apoptosis; multicellular organismal development; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; bone remodeling; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; morphogenesis of an epithelial sheet; heart looping; cell cycle arrest; cell growth; cell differentiation; positive regulation of BMP signaling pathway; regulation of developmental process; placenta development; embryonic limb morphogenesis; Notch signaling pathway; transcription, DNA-dependent; in utero embryonic development; humoral immune response; organ morphogenesis; inflammatory response to antigenic stimulus; defense response to bacterium; positive regulation of Ras protein signal transduction; determination of left/right symmetry