Potassium Channel Subfamily K Member 18, KCNK18 (KCNK18) ELISA Kit for Human

Name: Human KCNK18 ELISA Kit; Potassium Channel Subfamily K Member 18, KCNK18; MyBioSource
Brand: MyBioSource
SKU: MBS160432
Price: 425 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS160432

MBS160432 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Potassium channel subfamily K member 18, KCNK18, ELISA Kit target analytes in biological samples. The concentration gradients of… More details

$425 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Potassium channel subfamily K member 18, KCNK18, ELISA Kit

Full Product Name

Human Potassium channel subfamily K member 18, KCNK18 ELISA Kit

Product Gene Name

KCNK18 elisa kit

Species Reactivity

Human

Preparation and Storage

Store at 2 to 8 degree C for 6 months.

Molecular Weight

43,671 Da

3D Structure

ModBase 3D Structure for Q7Z418

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KCNK18 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNK18. It may not necessarily be applicable to this product.

NCBI GI #

32469495

NCBI GeneID

338567

NCBI Accession #

NP_862823.1

UniProt Primary Accession #

Q7Z418

UniProt Secondary Accession #

Q5SQQ8

UniProt Related Accession #

Q7Z418

GenBank Nucleotide #

NM_181840.1

NCBI Official Full Name

potassium channel subfamily K member 18

NCBI Official Synonym Full Names

potassium two pore domain channel subfamily K member 18

NCBI Official Symbol

KCNK18

NCBI Official Synonym Symbols

TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2

UniProt Protein Name

Potassium channel subfamily K member 18

UniProt Synonym Protein Names

TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel

Protein Family

Potassium channel subfamily

UniProt Gene Name

KCNK18

UniProt Synonym Gene Names

TRESK; TRIK

NCBI Protein Information

potassium channel subfamily K member 18

NCBI Summary for KCNK18

Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]

UniProt Comments for KCNK18

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation ().

Research Articles on KCNK18

1. The presence of SCN1A mutations and absence of mutations in ATP1A2 or CACNA1A suggest that the Polish patients represent FHM type 3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KCNK18 elisa kit

Reference Product	PubMed Publications
CACNA1A elisa kit	>3 publications with KCNK18 and CACNA1A
SCN1A elisa kit	>3 publications with KCNK18 and SCN1A
ATP1A2 elisa kit	>3 publications with KCNK18 and ATP1A2
MARK2 elisa kit	>1 publications with KCNK18 and MARK2

Pathways associated with KCNK18 elisa kit

Products by Pathway	Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
TWIK-related Spinal Cord K+ Channel (TRESK) Pathway antibodies	TWIK-related Spinal Cord K+ Channel (TRESK) Pathway Diagram
Tandem Pore Domain Potassium Channels Pathway antibodies	Tandem Pore Domain Potassium Channels Pathway Diagram

Diseases associated with KCNK18 elisa kit

Disease Name	Pubmed Publications
Migraine Disorders Antibodies	>10 publications with KCNK18 and Migraine Disorders