Transmembrane Protein 2 (TMEM2) ELISA Kit for Human

Name: Human TMEM2 ELISA Kit; Transmembrane Protein 2; MyBioSource
Brand: MyBioSource
SKU: MBS161034
Price: 435 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS161034

MBS161034 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Transmembrane Protein 2 (TMEM2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Product Name

Transmembrane Protein 2 (TMEM2), ELISA Kit

Full Product Name

Human Transmembrane Protein 2 (TMEM2) ELISA Kit

Product Gene Name

TMEM2 elisa kit

Species Reactivity

Human

Preparation and Storage

Store at 2 to 8 degree C for 6 months.

Molecular Weight

147,439 Da

3D Structure

ModBase 3D Structure for Q9UHN6

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TMEM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TMEM2. It may not necessarily be applicable to this product.

NCBI GI #

209447096

NCBI GeneID

23670

NCBI Accession #

NP_001129292.1

UniProt Primary Accession #

Q9UHN6

UniProt Secondary Accession #

Q5T838; Q5T839; Q5T840; Q5T841; Q8NBP6; Q9P2D5; A6H8W9; B2RTQ6

UniProt Related Accession #

Q9UHN6

GenBank Nucleotide #

NM_001135820.1

NCBI Official Full Name

cell surface hyaluronidase isoform b

NCBI Official Synonym Full Names

cell migration inducing hyaluronidase 2

NCBI Official Symbol

CEMIP2

NCBI Official Synonym Symbols

TMEM2

UniProt Protein Name

Cell surface hyaluronidase

UniProt Synonym Protein Names

Transmembrane protein 21 PublicationManual assertion based on opinion iniRef.1"Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2."Scott D.A., Drury S., Sundstrom R.A., Bishop J., Swiderski R.E., Carmi R., Ramesh A., Elbedour K., Srikumari Srisailapathy C.R., Keats B.J., Sheffield V.C., Smith R.J.H.Gene 246:265-274(2000) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.

Protein Family

Transmembrane protein

UniProt Gene Name

TMEM2

NCBI Protein Information

cell surface hyaluronidase

NCBI Summary for TMEM2

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]

UniProt Comments for TMEM2

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).

Research Articles on TMEM2

1. TMEM2 inhibits Hepatitis b virus infection in HepG2 and HepG2.2.15 by activating the JAK-STAT signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TMEM2 elisa kit

Reference Product	PubMed Publications
TMC1 elisa kit	>1 publications with TMEM2 and TMC1

Diseases associated with TMEM2 elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>1 publications with TMEM2 and Cardiovascular Diseases
Heart Defects, Congenital Antibodies	>1 publications with TMEM2 and Heart Defects, Congenital
Liver Diseases Antibodies	>1 publications with TMEM2 and Liver Diseases
Kidney Diseases Antibodies	>1 publications with TMEM2 and Kidney Diseases

Organs/Tissues associated with TMEM2 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with TMEM2 and Blood
Kidney Antibodies	>2 publications with TMEM2 and Kidney
Muscle Antibodies	>2 publications with TMEM2 and Muscle
Embryonic Tissue Antibodies	>2 publications with TMEM2 and Embryonic Tissue
Bone Antibodies	>1 publications with TMEM2 and Bone
Liver Antibodies	>1 publications with TMEM2 and Liver
Brain Antibodies	>1 publications with TMEM2 and Brain
Eye Antibodies	>1 publications with TMEM2 and Eye