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Angiotensinogen, Agt (aGT) ELISA Kit for Rat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS164609

Intended Uses: This sandwich kit is for the accurate quantitative detection of Rat Angiopoietin 1 (also known as ANG-1) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.Principle of the Assay: This kit is an Enzyme-Linked… More details

$445 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
angiotensinogen, aGT, ELISA Kit
Full Product Name
Rat angiotensinogen, aGT ELISA Kit
Product Gene Name
aGT elisa kit
Species Reactivity
Rat
Assay Type
Quantitative Sandwich
Samples
Serum, Plasma, Cell Culture Supernates, Cell Lysates, Tissue Homogenates
Detection Range
3ng/ml-900ng/ml
Sensitivity
1.62ng/ml
Preparation and Storage
Store at 2 to 8 degree C for 6 months.
Inter-assay Precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision. CV(%) = SD/mean x 100. Inter-Assay: CV<10%
Intra-assay Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision. Intra-Assay: CV<8%
Molecular Weight
53,154 Da
3D Structure
ModBase 3D Structure for P01019
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of aGT elisa kit

Rat aGT ELISA Kit – Cat# MBS164609

Other Notes

Small volumes of aGT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for aGT purchase

MBS164609 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the angiotensinogen, aGT, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing aGT. The ELISA analytical biochemical technique of the MBS164609 kit is based on aGT antibody-aGT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect aGT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, aGT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for aGT. It may not necessarily be applicable to this product.

NCBI GI #
532198
NCBI GeneID
183
NCBI Accession #
AAA51679.1
UniProt Primary Accession #
P01019
UniProt Secondary Accession #
Q16358; Q16359; Q96F91
UniProt Related Accession #
P01019
NCBI Official Full Name
angiotensinogen
NCBI Official Synonym Full Names
angiotensinogen
NCBI Official Symbol
AGT
NCBI Official Synonym Symbols
ANHU; hFLT1; SERPINA8
UniProt Protein Name
Angiotensinogen
UniProt Synonym Protein Names
Serpin A8
Protein Family
Angiotensinogen
UniProt Gene Name
AGT
UniProt Synonym Gene Names
SERPINA8; Ang I; Ang II; Ang III; Ang IV
NCBI Protein Information
angiotensinogen

NCBI Summary for aGT

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
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UniProt Comments for aGT

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.
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Research Articles on aGT

1. The ACE and AGT gene polymorphisms are not associated with the progress of diabetes developing into retinopathy in Chinese patients with type 2 diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with aGT elisa kit

 Reference Product  PubMed Publications
 ACE elisa kit  >419 publications with aGT and ACE
 AGTR1 elisa kit  >94 publications with aGT and AGTR1
 REN elisa kit  >53 publications with aGT and REN
 AGTR2 elisa kit  >51 publications with aGT and AGTR2
 ACE2 elisa kit  >26 publications with aGT and ACE2
 TGFB1 elisa kit  >22 publications with aGT and TGFB1
 IL6 elisa kit  >5 publications with aGT and IL6
 INS elisa kit  >4 publications with aGT and INS
 KNG1 elisa kit  >1 publications with aGT and KNG1

Pathways associated with aGT elisa kit

 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with aGT elisa kit

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >543 publications with aGT and Cardiovascular Diseases
 Hypertension Antibodies  >512 publications with aGT and Hypertension
 Kidney Diseases Antibodies  >249 publications with aGT and Kidney Diseases
 Heart Diseases Antibodies  >166 publications with aGT and Heart Diseases
 Hypertension, Renal Antibodies  >115 publications with aGT and Hypertension, Renal
 Myocardial Ischemia Antibodies  >98 publications with aGT and Myocardial Ischemia
 Hypertrophy Antibodies  >75 publications with aGT and Hypertrophy
 Atherosclerosis Antibodies  >67 publications with aGT and Atherosclerosis
 Myocardial Infarction Antibodies  >59 publications with aGT and Myocardial Infarction
 Proteinuria Antibodies  >58 publications with aGT and Proteinuria

Organs/Tissues associated with aGT elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >666 publications with aGT and Blood
 Kidney Antibodies  >283 publications with aGT and Kidney
 Liver Antibodies  >277 publications with aGT and Liver
 Heart Antibodies  >151 publications with aGT and Heart
 Brain Antibodies  >116 publications with aGT and Brain
 Lung Antibodies  >70 publications with aGT and Lung
 Muscle Antibodies  >66 publications with aGT and Muscle
 Bone Antibodies  >61 publications with aGT and Bone
 Connective Tissue Antibodies  >50 publications with aGT and Connective Tissue
 Ovary Antibodies  >38 publications with aGT and Ovary
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