Ryanodine Receptor 1, Ryr1 (RyR1) ELISA Kit for Human

Name: Human RyR1 ELISA Kit; Ryanodine Receptor 1, Ryr1; MyBioSource
Brand: MyBioSource
SKU: MBS164873
Price: 425 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS164873

Intended Uses: This sandwich kit is for the accurate quantitative detection of human Ryanodine Receptor (also known as RyR) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.Principles of the Assay: This kit is an Enzyme-Linked… More details

$425 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Ryanodine receptor 1, RyR1, ELISA Kit

Full Product Name

Human Ryanodine receptor 1, RyR1 ELISA Kit

Product Gene Name

RyR1 elisa kit

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Samples

Serum, plasma, cell culture supernates, cell lysates, tissue homogenates

Detection Range

0.1ng/ml - 30ng/ml

Sensitivity

0.05ng/ml

Preparation and Storage

Store at 2 to 8 degree C for 6 months.

Molecular Weight

565,039 Da

3D Structure

ModBase 3D Structure for E9PZQ0

Intra-Assay

CV<8%

Inter-Assay

CV<10%

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RyR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RyR1 purchase

MBS164873 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ryanodine receptor 1, RyR1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RyR1. The ELISA analytical biochemical technique of the MBS164873 kit is based on RyR1 antibody-RyR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RyR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RyR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for RyR1. It may not necessarily be applicable to this product.

NCBI GI #

145046267

NCBI GeneID

20190

NCBI Accession #

NP_033135.2

UniProt Primary Accession #

E9PZQ0

UniProt Secondary Accession #

Q60834; Q61779; Q61780; Q62173; Q62196; Q62235; Q78EJ6; Q7TNG1; Q80UQ5; Q80X16; Q99JF9

UniProt Related Accession #

E9PZQ0

GenBank Nucleotide #

NM_009109.2

NCBI Official Full Name

ryanodine receptor 1

NCBI Official Synonym Full Names

ryanodine receptor 1, skeletal muscle

NCBI Official Symbol

Ryr1

NCBI Official Synonym Symbols

Ryr; skrr; RYR-1; AI528790

UniProt Protein Name

Ryanodine receptor 1

UniProt Synonym Protein Names

Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor

Protein Family

Ryanodine receptor

UniProt Gene Name

Ryr1

UniProt Synonym Gene Names

RYR-1; RyR1

NCBI Protein Information

ryanodine receptor 1

UniProt Comments for RyR1

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18003898, PubMed:7515481, PubMed:7621815, PubMed:21156754). Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain (PubMed:22036948). Required for normal embryonic development of muscle fibers and skeletal muscle (PubMed:7515481). Required for normal heart morphogenesis, skin development and ossification during embryogenesis (PubMed:18003898, PubMed:7515481).

Research Articles on RyR1

1. Results suggest distinct functional roles for type 1 ryanodine receptor (RYR1) and Ca2+ channels-the 1,4-dihydropyridine receptor (Cav1.1) in skeletal primary and secondary myogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RyR1 elisa kit

Reference Product	PubMed Publications
Ryr3 elisa kit	>5094 publications with RyR1 and Ryr3
Casq2 elisa kit	>51 publications with RyR1 and Casq2
Trpc3 elisa kit	>14 publications with RyR1 and Trpc3
Casq1 elisa kit	>13 publications with RyR1 and Casq1
Cacna1c elisa kit	>2 publications with RyR1 and Cacna1c
Calm1 elisa kit	>1 publications with RyR1 and Calm1

Pathways associated with RyR1 elisa kit

Products by Pathway	Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
Circadian Entrainment Pathway antibodies	Circadian Entrainment Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Long-term Depression Pathway antibodies	Long-term Depression Pathway Diagram
Long-term Depression Pathway antibodies	Long-term Depression Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram

Diseases associated with RyR1 elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>806 publications with RyR1 and Cardiovascular Diseases
Heart Diseases Antibodies	>786 publications with RyR1 and Heart Diseases
Malignant Hyperthermia Antibodies	>529 publications with RyR1 and Malignant Hyperthermia
Disease Models, Animal Antibodies	>194 publications with RyR1 and Disease Models, Animal
Myopathies, Structural, Congenital Antibodies	>140 publications with RyR1 and Myopathies, Structural, Congenital
Myopathy, Central Core Antibodies	>132 publications with RyR1 and Myopathy, Central Core
Drug Toxicity Antibodies	>100 publications with RyR1 and Drug Toxicity
Brain Diseases Antibodies	>93 publications with RyR1 and Brain Diseases
Neoplasms Antibodies	>85 publications with RyR1 and Neoplasms
Congenital Abnormalities Antibodies	>66 publications with RyR1 and Congenital Abnormalities

Organs/Tissues associated with RyR1 elisa kit

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>3821 publications with RyR1 and Muscle
Other Antibodies	>760 publications with RyR1 and Other
Brain Antibodies	>532 publications with RyR1 and Brain
Embryonic Tissue Antibodies	>114 publications with RyR1 and Embryonic Tissue
Eye Antibodies	>45 publications with RyR1 and Eye
Intestine Antibodies	>43 publications with RyR1 and Intestine
Thymus Antibodies	>34 publications with RyR1 and Thymus
Ovary Antibodies	>25 publications with RyR1 and Ovary
Inner Ear Antibodies	>17 publications with RyR1 and Inner Ear
Skin Antibodies	>12 publications with RyR1 and Skin