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CXC-Chemokine Receptor 4, CXCR4 (CXCR4) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS165017

Intended Uses: This sandwich kit is for the accurate quantitative detection of human CXC-chemokine Receptor 3 (also known as CXCR3) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.Principle of the Assay: This kit is an… More details

$425 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXC-chemokine receptor 4, CXCR4, ELISA Kit
Full Product Name
Human CXC-chemokine receptor 4, CXCR4 ELISA Kit
Product Gene Name
CXCR4 elisa kit
Species Reactivity
Human
Assay Type
Quantitative Sandwich
Samples
Serum, Plasma, Cell Culture Supernates, Cell Lysates, Tissue Homogenates
Detection Range
20ng/L-3500ng/L
Sensitivity
10.26ng/L
Preparation and Storage
Store at 2 to 8 degree C for 6 months.
Inter-assay Precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision. CV(%) = SD/mean x 100. Inter-Assay: CV<10%
Intra-assay Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision. Intra-Assay: CV<8%
Molecular Weight
40,221 Da
3D Structure
ModBase 3D Structure for P61073
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of CXCR4 elisa kit

Human CXCR4 ELISA Kit – Cat# MBS165017

Other Notes

Small volumes of CXCR4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR4 purchase

MBS165017 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CXC-chemokine receptor 4, CXCR4, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CXCR4. The ELISA analytical biochemical technique of the MBS165017 kit is based on CXCR4 antibody-CXCR4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CXCR4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CXCR4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR4. It may not necessarily be applicable to this product.

NCBI GI #
3059120
NCBI GeneID
7852
NCBI Accession #
CAA12166.1
UniProt Primary Accession #
P61073
UniProt Secondary Accession #
O60835; P30991; P56438; Q53S69; Q9BXA0; Q9UKN2; B2R5N0
UniProt Related Accession #
P61073
NCBI Official Full Name
CXCR4
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 4
NCBI Official Symbol
CXCR4
NCBI Official Synonym Symbols
FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E
UniProt Protein Name
C-X-C chemokine receptor type 4
UniProt Synonym Protein Names
FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
CXCR4
UniProt Synonym Gene Names
CXC-R4; CXCR-4; LESTR; LAP-3; LPS-associated protein 3; SDF-1 receptor
NCBI Protein Information
C-X-C chemokine receptor type 4

NCBI Summary for CXCR4

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for CXCR4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
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Research Articles on CXCR4

1. These results suggest that SDF1 (e.g. presented on proteoglycans) can rapidly activate integrins in an allosteric manner by binding to site 2 in the absence of CXCR4. The allosteric integrin activation by SDF1 is a novel target for drug discovery

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CXCR4 elisa kit

 Reference Product  PubMed Publications
 CXCL12 elisa kit  >2826 publications with CXCR4 and CXCL12
 CD4 elisa kit  >1976 publications with CXCR4 and CD4
 CCL2 elisa kit  >132 publications with CXCR4 and CCL2
 PTPRC elisa kit  >114 publications with CXCR4 and PTPRC
 HIF1A elisa kit  >74 publications with CXCR4 and HIF1A
 RAC1 elisa kit  >36 publications with CXCR4 and RAC1
 ITCH elisa kit  >8 publications with CXCR4 and ITCH
 SDC4 elisa kit  >5 publications with CXCR4 and SDC4
 ADRBK1 elisa kit  >3 publications with CXCR4 and ADRBK1
 UBC elisa kit  >3 publications with CXCR4 and UBC

Pathways associated with CXCR4 elisa kit

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Entry Of HIV Virion Pathway antibodies  Binding And Entry Of HIV Virion Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with CXCR4 elisa kit

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1790 publications with CXCR4 and Neoplasms
 Inflammation Antibodies  >533 publications with CXCR4 and Inflammation
 Neoplasm Metastasis Antibodies  >508 publications with CXCR4 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >419 publications with CXCR4 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >377 publications with CXCR4 and Nervous System Diseases
 Breast Neoplasms Antibodies  >345 publications with CXCR4 and Breast Neoplasms
 Necrosis Antibodies  >242 publications with CXCR4 and Necrosis
 Lung Neoplasms Antibodies  >191 publications with CXCR4 and Lung Neoplasms
 Ischemia Antibodies  >189 publications with CXCR4 and Ischemia
 Neoplasms, Experimental Antibodies  >187 publications with CXCR4 and Neoplasms, Experimental

Organs/Tissues associated with CXCR4 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3315 publications with CXCR4 and Blood
 Bone Antibodies  >1345 publications with CXCR4 and Bone
 Bone Marrow Antibodies  >1190 publications with CXCR4 and Bone Marrow
 Vascular Antibodies  >837 publications with CXCR4 and Vascular
 Brain Antibodies  >583 publications with CXCR4 and Brain
 Lung Antibodies  >392 publications with CXCR4 and Lung
 Lymph Node Antibodies  >362 publications with CXCR4 and Lymph Node
 Lymph Antibodies  >354 publications with CXCR4 and Lymph
 Liver Antibodies  >347 publications with CXCR4 and Liver
 Muscle Antibodies  >273 publications with CXCR4 and Muscle
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