Human CYP27B1 ELISA Kit – Cat# MBS167210

25-Hydroxyvitamin D-1 Alpha Hydroxylase, Mitochondrial (CYP27B1) ELISA Kit for Human

Name: Human CYP27B1 ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS167210
Price: 425 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS167210

MBS167210 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) ELISA Kit target analytes in biological samples. The… More details

$425 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1), ELISA Kit

Full Product Name

Human 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) ELISA Kit

Product Gene Name

CYP27B1 elisa kit

Species Reactivity

Human

Preparation and Storage

Store at 2 to 8 degree C for 6 months.

Molecular Weight

56,504 Da

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CYP27B1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP27B1. It may not necessarily be applicable to this product.

NCBI GI #

2612926

NCBI GeneID

1594

NCBI Accession #

AAC51853.1

UniProt Secondary Accession #

Q548T3; B2RC61

UniProt Related Accession #

O15528

NCBI Official Full Name

25-hydroxyvitamin D-1-alpha-hydroxylase

NCBI Official Synonym Full Names

cytochrome P450 family 27 subfamily B member 1

NCBI Official Symbol

CYP27B1

NCBI Official Synonym Symbols

VDR; CP2B; CYP1; PDDR; VDD1; VDDR; VDDRI; CYP27B; P450c1; CYP1alpha

UniProt Protein Name

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

UniProt Synonym Protein Names

25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; VD3 1A hydroxylase; Calcidiol 1-monooxygenase; Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; Cytochrome p450 27B1

Protein Family

25-hydroxyvitamin D-1 alpha hydroxylase

UniProt Gene Name

CYP27B1

UniProt Synonym Gene Names

CYP1ALPHA; CYP27B; VD3 1A hydroxylase

NCBI Protein Information

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

NCBI Summary for CYP27B1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]

UniProt Comments for CYP27B1

Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)3D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.

Research Articles on CYP27B1

1. Expression analysis showed significant CYP27B1 upregulation in epileptic male patients aged between 30 and 40.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CYP27B1 elisa kit

Reference Product	PubMed Publications
CYP24A1 elisa kit	>429 publications with CYP27B1 and CYP24A1
VDR elisa kit	>325 publications with CYP27B1 and VDR
PTH elisa kit	>146 publications with CYP27B1 and PTH
FGF23 elisa kit	>44 publications with CYP27B1 and FGF23
TLR2 elisa kit	>12 publications with CYP27B1 and TLR2
AHR elisa kit	>1 publications with CYP27B1 and AHR

Pathways associated with CYP27B1 elisa kit

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Cholecalciferol Biosynthesis Pathway antibodies	Cholecalciferol Biosynthesis Pathway Diagram
Cholecalciferol Biosynthesis Pathway antibodies	Cholecalciferol Biosynthesis Pathway Diagram
Cytochrome P450 - Arranged By Substrate Type Pathway antibodies	Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Fat-soluble Vitamins Pathway antibodies	Metabolism Of Fat-soluble Vitamins Pathway Diagram
Metabolism Of Vitamins And Cofactors Pathway antibodies	Metabolism Of Vitamins And Cofactors Pathway Diagram
Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies	Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Phase 1 - Functionalization Of Compounds Pathway antibodies	Phase 1 - Functionalization Of Compounds Pathway Diagram

Diseases associated with CYP27B1 elisa kit

Disease Name	Pubmed Publications
Rickets Antibodies	>153 publications with CYP27B1 and Rickets
Kidney Diseases Antibodies	>134 publications with CYP27B1 and Kidney Diseases
Disease Models, Animal Antibodies	>57 publications with CYP27B1 and Disease Models, Animal
Hypercalcemia Antibodies	>53 publications with CYP27B1 and Hypercalcemia
Inflammation Antibodies	>50 publications with CYP27B1 and Inflammation
Renal Insufficiency Antibodies	>47 publications with CYP27B1 and Renal Insufficiency
Breast Neoplasms Antibodies	>43 publications with CYP27B1 and Breast Neoplasms
Prostatic Neoplasms Antibodies	>42 publications with CYP27B1 and Prostatic Neoplasms
Liver Diseases Antibodies	>34 publications with CYP27B1 and Liver Diseases
Hypertension Antibodies	>25 publications with CYP27B1 and Hypertension

Organs/Tissues associated with CYP27B1 elisa kit

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>546 publications with CYP27B1 and Kidney
Blood Antibodies	>388 publications with CYP27B1 and Blood
Bone Antibodies	>279 publications with CYP27B1 and Bone
Intestine Antibodies	>114 publications with CYP27B1 and Intestine
Muscle Antibodies	>32 publications with CYP27B1 and Muscle
Brain Antibodies	>31 publications with CYP27B1 and Brain
Lung Antibodies	>30 publications with CYP27B1 and Lung
Uterus Antibodies	>14 publications with CYP27B1 and Uterus
Mammary Gland Antibodies	>12 publications with CYP27B1 and Mammary Gland
Pancreas Antibodies	>8 publications with CYP27B1 and Pancreas