C-Type Lectin Domain Family 7 Member A (CLEC7A) ELISA Kit for Human

Name: Human CLEC7A ELISA Kit; C-Type Lectin Domain Family 7 Member A; MyBioSource
Brand: MyBioSource
SKU: MBS167360
Price: 425 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS167360

Intended Uses: This sandwich kit is for the accurate quantitative detection of human C-type Lectin Domain Family 7 Member A (also known as CLEC7A) in serum, plasma, cell culture supernates, cell lysates, tissue homogenates.Principles of the Assay: This kit is… More details

$425 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

C-type lectin domain family 7 member A (CLEC7A), ELISA Kit

Full Product Name

Human C-type lectin domain family 7 member A (CLEC7A) ELISA Kit

Product Gene Name

CLEC7A elisa kit

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Samples

Serum, plasma, cell culture supernates, cell lysates, tissue homogenates

Detection Range

10ng/L - 3000ng/L

Sensitivity

5.14ng/L

Preparation and Storage

Store at 2 to 8 degree C for 6 months.

Molecular Weight

22,563 Da

3D Structure

ModBase 3D Structure for Q9BXN2

Intra-Assay

CV<8%

Inter-Assay

CV<10%

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CLEC7A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC7A purchase

MBS167360 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the C-type lectin domain family 7 member A (CLEC7A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CLEC7A. The ELISA analytical biochemical technique of the MBS167360 kit is based on CLEC7A antibody-CLEC7A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CLEC7A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CLEC7A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC7A. It may not necessarily be applicable to this product.

NCBI GI #

13384604

NCBI GeneID

64581

NCBI Accession #

NP_072092.2

UniProt Primary Accession #

Q9BXN2

UniProt Secondary Accession #

Q6IPS7; Q96D32; Q96DR9; Q96LD3; Q96PA4; Q96PA5; Q96PA6; B2R861; B7Z494; B7Z5A9; B7Z5B9

UniProt Related Accession #

Q9BXN2

GenBank Nucleotide #

NM_022570.4

NCBI Official Full Name

C-type lectin domain family 7 member A isoform b

NCBI Official Synonym Full Names

C-type lectin domain containing 7A

NCBI Official Symbol

CLEC7A

NCBI Official Synonym Symbols

BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12

UniProt Protein Name

C-type lectin domain family 7 member A

UniProt Synonym Protein Names

Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1

Protein Family

C-type lectin domain family

UniProt Gene Name

CLEC7A

UniProt Synonym Gene Names

BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1

NCBI Protein Information

C-type lectin domain family 7 member A

NCBI Summary for CLEC7A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

UniProt Comments for CLEC7A

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation ().

Research Articles on CLEC7A

1. Dectin-1 receptor blockage decreased the IL-12, IL-17, IL-10 and TNF-alpha levels indicating the participation of such receptor in the induction of these cytokines.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CLEC7A elisa kit

Products by Pathway	Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Diseases associated with CLEC7A elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>11 publications with CLEC7A and Inflammation
Necrosis Antibodies	>5 publications with CLEC7A and Necrosis
Lung Diseases Antibodies	>2 publications with CLEC7A and Lung Diseases
Colitis Antibodies	>2 publications with CLEC7A and Colitis
Atherosclerosis Antibodies	>1 publications with CLEC7A and Atherosclerosis
Liver Cirrhosis Antibodies	>1 publications with CLEC7A and Liver Cirrhosis
Non-alcoholic Fatty Liver Disease Antibodies	>1 publications with CLEC7A and Non-alcoholic Fatty Liver Disease
Fatty Liver Antibodies	>1 publications with CLEC7A and Fatty Liver
Neoplasms Antibodies	>1 publications with CLEC7A and Neoplasms
Liver Diseases Antibodies	>1 publications with CLEC7A and Liver Diseases

Organs/Tissues associated with CLEC7A elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>20 publications with CLEC7A and Blood
Lung Antibodies	>6 publications with CLEC7A and Lung
Bone Marrow Antibodies	>3 publications with CLEC7A and Bone Marrow
Intestine Antibodies	>2 publications with CLEC7A and Intestine
Vascular Antibodies	>1 publications with CLEC7A and Vascular
Spleen Antibodies	>1 publications with CLEC7A and Spleen