Mannose-Binding Lectin (Protein C) 2, Soluble (Opsonic Defect) (MBL2) ELISA Kit for Human

Name: Human MBL2 ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS702657
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS702657

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for MBP/MBL has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any MBP/MBL present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

mannose-binding lectin (protein C) 2, soluble (opsonic defect) (MBL2), ELISA Kit

Full Product Name

Human Mannma binding protein/mannan binding lectin, MBP/MBL ELISA Kit

Product Gene Name

MBL2 elisa kit

Product Synonym Names

Human Mannma binding protein/mannan binding lectin; MBP/MBL ELISA Kit; COLEC1; HSMBPC; MBL; MBP; MBP1; MGC116832; MGC116833; mannan-binding lectin; mannose-binding lectin 2; soluble (opsonic defect) ; mannose-binding protein C; soluble mannose-binding lectin; Human Mannma binding protein/mannan binding lectin; MBP/MBL

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum

Detection Range

1.563 ng/ml-100 ng/ml

Sensitivity

0.171ng/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of Human MBL2. No significant cross-reactivity or interference between Human MBL2 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.

Molecular Weight

26,144 Da

OMIM

614372

3D Structure

ModBase 3D Structure for P11226

Detection Wavelength

450 nm

Sample Volume

50-100ul

Protein Biological Process 1

others

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MBL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MBL2 purchase

MBS702657 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the mannose-binding lectin (protein C) 2, soluble (opsonic defect) (MBL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MBL2. The ELISA analytical biochemical technique of the MBS702657 kit is based on MBL2 antibody-MBL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MBL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MBL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for MBL2. It may not necessarily be applicable to this product.

NCBI GI #

4557739

NCBI GeneID

4153

NCBI Accession #

NP_000233.1

UniProt Primary Accession #

P11226

UniProt Secondary Accession #

Q4VB12; Q4VB13; Q4VB14; Q5SQS3; Q86SI4; Q96KE4; Q96TF7; Q96TF8; Q96TF9

UniProt Related Accession #

P11226

GenBank Nucleotide #

NM_000242.2

NCBI Official Full Name

mannose-binding protein C

NCBI Official Synonym Full Names

mannose-binding lectin (protein C) 2, soluble

NCBI Official Symbol

MBL2

NCBI Official Synonym Symbols

MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC

UniProt Protein Name

Mannose-binding protein C

UniProt Synonym Protein Names

Collectin-1; MBP1; Mannan-binding protein; Mannose-binding lectin

Protein Family

Mannose-binding protein

UniProt Gene Name

MBL2

UniProt Synonym Gene Names

COLEC1; MBL; MBP-C

UniProt Entry Name

MBL2_HUMAN

NCBI Protein Information

mannose-binding protein C; collectin-1; mannan-binding lectin; mannose-binding lectin 2, soluble (opsonic defect); mannose-binding lectin (protein C) 2, soluble (opsonic defect)

NCBI Summary for MBL2

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]

UniProt Comments for MBL2

Function: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.1 PublicationManual assertion based on experiment in:Ref.14

Research Articles on MBL2

1. MBL could directly bind to PMA-activated THP-1 cells in the presence of Ca(2+), and this binding decreased TLR2 and TLR4 expressions in C. albicans-induced THP-1 macrophages.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MBL2 elisa kit

Reference Product	PubMed Publications
MASP2 elisa kit	>35 publications with MBL2 and MASP2
FCN2 elisa kit	>16 publications with MBL2 and FCN2
MASP1 elisa kit	>7 publications with MBL2 and MASP1
C1S elisa kit	>4 publications with MBL2 and C1S
INS elisa kit	>3 publications with MBL2 and INS

Pathways associated with MBL2 elisa kit

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram

Diseases associated with MBL2 elisa kit

Disease Name	Pubmed Publications
Infection Antibodies	>199 publications with MBL2 and Infection
Inflammation Antibodies	>79 publications with MBL2 and Inflammation
Liver Diseases Antibodies	>31 publications with MBL2 and Liver Diseases
Fibrosis Antibodies	>27 publications with MBL2 and Fibrosis
HIV Infections Antibodies	>25 publications with MBL2 and HIV Infections
Hepatitis Antibodies	>20 publications with MBL2 and Hepatitis
Heart Diseases Antibodies	>19 publications with MBL2 and Heart Diseases
Necrosis Antibodies	>18 publications with MBL2 and Necrosis
Disease Models, Animal Antibodies	>13 publications with MBL2 and Disease Models, Animal
Atherosclerosis Antibodies	>12 publications with MBL2 and Atherosclerosis

Organs/Tissues associated with MBL2 elisa kit

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>13 publications with MBL2 and Bone
Connective Tissue Antibodies	>4 publications with MBL2 and Connective Tissue
Heart Antibodies	>3 publications with MBL2 and Heart
Muscle Antibodies	>3 publications with MBL2 and Muscle
Brain Antibodies	>3 publications with MBL2 and Brain
Vascular Antibodies	>2 publications with MBL2 and Vascular
Embryonic Tissue Antibodies	>2 publications with MBL2 and Embryonic Tissue
Ear Antibodies	>1 publications with MBL2 and Ear
Kidney Antibodies	>1 publications with MBL2 and Kidney
Umbilical Cord Antibodies	>1 publications with MBL2 and Umbilical Cord