RalBP1 PBD Accessory Reagent – Small Gtpase Assay Beads

• Pull down the active form of Ral
• Colored for easy visualization

Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. Ral, a 24 kDa protein of the Ras superfamily, regulates a variety of biological response pathways that include vesicle trafficking, cytoskeletal rearrangment, and migration. The Ras-like proteins RalA and RalB share 85% identity. Like other small GTPases, Ral regulates molecular events by cycling between an inactive GDP bound form and an active GTP-bound form. In their active (GTP-bound) state, Ral A and Ral B bind specifically to the protein-binding domain (PBD) of RalBP1 to control downstream signaling cascades.

1. Wolthuis RM, Franke B, van Triest M, et al. (1998) Mol Cell Biol 18:2486-2491.
2. Herrmann C, Horn G, Spaargaren M, Wittinghofer A (1996) J Biol Chem 271:6794-6800.
3. Ward Y, Wang W, Woodhouse E, et al. (2001) Mol Cell Biol 21:5958-5969.
4. Oxford G, Owens CR, Titus BJ, et al. (2005) Cancer Res 65:7111-7120.

Small volumes of RalBP1 PBD accessory reagent vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS168365 is an accessory reagent targeting RalBP1 PBD. Also known as RalBP1 PBD Agarose Beads.