Protein Tyrosine Nitration Control (Nitrotyrosine-BSA) Native Protein

• Provided at 0.1 mg/mL

Nitric oxide (NO) was initially identified as a muscle relaxation factor, mediating its effects on smooth muscle by coordinating the heme moiety of guanylate cyclase, leading to enhanced production of cGMP. Besides smooth muscle relaxation, NO also influences a variety of biological systems including cell proliferation, apoptosis, neurotoxicity, Parkinson disease, extracellular matrix remodeling. Many of its effects are mediated through protein nitrosylation.

Peroxynitrite (ONOO-) is formed in the chemical reaction between nitric oxide and superoxide. ONOO- nitrates free tyrosine and tyrosine residues in proteins; modifications that are used as markers of ONOO- action under conditions of cellular damage and in numerous diseases.

This control is manufactured by nitration of bovine serum albumin in vitro using peroxynitrite as the NO donor.

1. Halliwell, B., Zhao, K., and Whiteman, M. (1999) Free Radic. Res. 31, 651-669.
2. Greenacre, S. A. B., and Ischiropoulos, H. (2001) Free Radic. Res. 34, 541-581.

Small volumes of Protein Tyrosine Nitration Control (Nitrotyrosine-BSA) native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS168846 is a native protein targeting Protein Tyrosine Nitration Control (Nitrotyrosine-BSA).