Prostatic Acid Phosphatase (ACPP) Enzyme

Name: ACPP Enzyme; Prostatic Acid Phosphatase; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS173169
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Popular Catalog #: MBS173169

MyBioSource produces human seminal fluid Prostatic Acid Phosphatase (PAP/ACP) for research and bulk IVD manufacturing.Custom preparations, technical support, bulk quantities and aliquoting available.MyBioSource has an extensive human semen donor program.… More details

$495 / 1000 Units +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Prostatic Acid Phosphatase (ACPP), Enzyme

Full Product Name

Prostatic Acid Phosphatase (PAP/ACP), Human - High Purity

Product Gene Name

ACPP enzyme

Product Synonym Gene Name

5'-NT; ACP-3; ACP3; PAP

Product Synonym Names

ACP; PAP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; Prostatic Acid Phosphatase (ACP, PAP), Human Semen - >=98% (SDS-PAGE) - Lyophilized

Form/Format

Powder, lyophilized from 50 mM sodium citrate, 75 mM sodium chloride, pH 6.5

Purity/Purification

> 98% (SDS-PAGE)

Preparation and Storage

Aliquot and freeze at -20 degree C after reconstitution.

OMIM

gene 200950

3D Structure

ModBase 3D Structure for P11117

Source

Human Prostatic Fluid (Semen)

EC Number

3.1.3.2

Appearance

Off-white to white powder

Solubility

Clear, colorless (10 mg/mL water)

Activity

130 units/mg solid

Unit Definition

One unit will catalyze the hydrolysis of one micromole of thymolphthalein monophosphate to thymolphthalein and phosphate per minute at pH 5.6 and 37 degree C.

Specific Activity

200 units/mg protein

7.0 (10 mg/mL water)

CAS Number

9001-77-8

Protein

0.65 mg/mg solid (Coomassie)

Ammonia

<0.01 umole/mg solid

Note

Reconstitute in provided container and centrifuge to ensure full recovery.

Product Categories/Family for ACPP enzyme

Proteins; Protein Antigens; Protein Enzymes; Standards/Controls; Native Proteins; Immunogen

Other Notes

Small volumes of ACPP enzyme vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACPP purchase

Proteins are activated with phosphate (kinases) and deactivated by acid phosphatase activity. The major prostate localized phosphatase is prostatic acid phosphatase PAP/ ACP. This human protein has been sequence determined and is known to be elevated in disease states like prostate cancer. Unlike cell secretase activity which cleaves proteins to inactivate them, PAP and related ACPP, APP, APHA and APPA homologues remove PO4 groups making them attractive therapeutic target candidates. By their activity they areinferred to undo close protein-protein interactions leading to cellular signaling shutdown. WB are the best test for phospho specific states but modern combination experimental techniques such as tandem LC MS increase detection. Add that to newly developed experimental computational analyses and actual or inferred protein sequence data, and high powered pathway analysis become possible. At MyBiosource, we strive to use all available PMC free resources to aid inferred combinatorial experimentation to unravel key cellular pathways.

Additional Details

NCBI/Uniprot data below describe general gene information for ACPP. It may not necessarily be applicable to this product.

NCBI GI #

1199524

NCBI GeneID

NCBI Accession #

CAA33542.1

UniProt Primary Accession #

P11117

UniProt Secondary Accession #

Q561W5; Q9BTU7; E9PCI1

UniProt Related Accession #

P11117

NCBI Official Full Name

acid phosphatase

NCBI Official Synonym Full Names

acid phosphatase 2, lysosomal

NCBI Official Symbol

ACP2

NCBI Official Synonym Symbols

LAP

UniProt Protein Name

Lysosomal acid phosphatase

Protein Family

Acyl carrier protein

UniProt Gene Name

ACP2

UniProt Synonym Gene Names

LAP

UniProt Entry Name

PPAL_HUMAN

NCBI Protein Information

lysosomal acid phosphatase

NCBI Summary for ACPP

This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

UniProt Comments for ACPP

ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family.

Protein type: Cofactor and Vitamin Metabolism - riboflavin; Phosphatase (non-protein); EC 3.1.3.2; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p11.2|11p12-p11

Cellular Component: lysosomal lumen; membrane; lysosomal membrane; lysosome; integral to membrane

Molecular Function: acid phosphatase activity

Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development

Disease: Acid Phosphatase Deficiency

Research Articles on ACPP

1. An enzymatically inactive allele of mouse Acp2 causes cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ACPP enzyme

Reference Product	PubMed Publications
ACP1 enzyme	>23 publications with ACPP and ACP1
LDHA enzyme	>6 publications with ACPP and LDHA
CTSD enzyme	>1 publications with ACPP and CTSD
ACP5 enzyme	>1 publications with ACPP and ACP5

Pathways associated with ACPP enzyme

Products by Pathway	Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Riboflavin Metabolism Pathway antibodies	Riboflavin Metabolism Pathway Diagram
Riboflavin Metabolism Pathway antibodies	Riboflavin Metabolism Pathway Diagram

Diseases associated with ACPP enzyme

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>5 publications with ACPP and Nervous System Diseases
Adenocarcinoma Antibodies	>1 publications with ACPP and Adenocarcinoma
Aneuploidy Antibodies	>1 publications with ACPP and Aneuploidy
Chromosome Aberrations Antibodies	>1 publications with ACPP and Chromosome Aberrations
Liver Neoplasms Antibodies	>1 publications with ACPP and Liver Neoplasms
Liver Neoplasms, Experimental Antibodies	>1 publications with ACPP and Liver Neoplasms, Experimental
Carcinoma, Hepatocellular Antibodies	>1 publications with ACPP and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>1 publications with ACPP and Liver Diseases

Organs/Tissues associated with ACPP enzyme

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>9 publications with ACPP and Liver
Blood Antibodies	>8 publications with ACPP and Blood
Brain Antibodies	>6 publications with ACPP and Brain
Spleen Antibodies	>2 publications with ACPP and Spleen
Bone Marrow Antibodies	>2 publications with ACPP and Bone Marrow
Bone Antibodies	>2 publications with ACPP and Bone
Muscle Antibodies	>2 publications with ACPP and Muscle
Skin Antibodies	>2 publications with ACPP and Skin
Placenta Antibodies	>1 publications with ACPP and Placenta
Prostate Antibodies	>1 publications with ACPP and Prostate