Thyroid Stimulating Hormone (TSH) Active Protein

MyBioSource offers High Purity Thyroid Stimulating Hormone (TSH) for clinical research and IVD bulk manufacturing.

Technical support, bulk quantities and custom buffers and aliquoting available.

Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a peptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH is a glycoprotein and consists of two subunits, the alpha and the beta subunit.

The TSH test is often the test of choice for evaluating thyroid function and/or symptoms of hyperthyroidism or hypothyroidism. It is frequently ordered along with or preceding a T4 test. Other thyroid tests that may be ordered include a T3 test and thyroid antibodies (if autoimmune-related thyroid disease is suspected).

according to Labtest online: A high TSH result often means an underactive thyroid gland that is not responding adequately to the stimulation of TSH due to some type of acute or chronic thyroid dysfunction. Rarely, a high TSH result can indicate a problem with the pituitary gland, such as a tumor producing unregulated levels of TSH. A high value can also occur when someone with a known thyroid disorder or who has had their thyroid gland removed is receiving too little thyroid hormone medication.

A low TSH result can indicate an overactive thyroid gland (hyperthyroidism) or excessive amounts of thyroid hormone medication in those who are being treated for an underactive (or removed) thyroid gland. Rarely, a low TSH result may indicate damage to the pituitary gland that prevents it from producing adequate amounts of TSH.

Small volumes of TSH active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Thyroid Stimulating Hormone TSH is best described as one of the few master cellular and physiological regulators. Transcribed and translated by anterior pituitary, when the protein is released, it binds to specific TSHR to stimulate production of thyroid hormones ( thyrotropin ) - classical endocrinol feedback loops. Research is still needed to unravel the complexities of THR - thyrotropin receptor - and TSH interactions and effects of genetic mutations and natural variants on human metabolism. Many variant SNPs have been identified but little is known how sequence differences effects target interactions. Some clin data is found in Europe PMC abstract cited as ref on the datasheet included with MyBiosource TSH human protein. Our native protein has been purified from human pituitary and fully characterized by SDS Page to meet your exacting research standards. You want to know more endocrinol metab oloic information, use our TSH!