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Pepsinogen II (PGC) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS173574

MyBioSource is the leading producer and supplier of Human Pepsinogen II/C antigen as a stomach gastric cancer marker for medical research, clinical and manufacturing.Custom preparations, technical support, bulk quantities and aliquoting available.Human… More details

$600 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pepsinogen II (PGC), Active Protein
Full Product Name
Pepsinogen II (PGII/PGC), Human Gastric Mucosa
Product Gene Name
PGC active protein
Product Synonym Gene Name
RP11-298J23.1; PEPC; PGII
Product Synonym Names
Pepsinogen C; PG II; PGC; Gastricsin; Pepsinogen II (PGII, PGC) - >=90% (SDS-PAGE) - Lyophilized
Host
Human gastric mucosa
Form/Format
Powder, lyophilized from tris chloride, pH 8.5
Purity/Purification
>90% (SDS-PAGE) may contain minor cleavage products.
Preparation and Storage
Store at -20°C.
Molecular Weight
40,600
OMIM
169740
3D Structure
ModBase 3D Structure for P20142
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Appearance
White to off-white powder.
Solubility
Clear, colorless (1mg/mL 0.02 M Tris-Chloride, pH= 8.0 buffer)
Protein
1.4 mg protein /vial (E 0.1%280nm= 1.43)
Specific Activity
2,920 U/mg protein (after activation)
Unit Definition
One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.
Identity
Confirmed by Western Blot.
Handling
Handle as a potentially hazardous substance
Reconstitution
After reconstitution maintain at or above pH 8.0 to avoid activation.

Product Categories/Family for PGC active protein

Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Pepsinogen Ii (pgii; Pgc)
Applications Tested/Suitable for PGC active protein
Western Blot (WB)

Other Notes

Small volumes of PGC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGC purchase

MBS173574 is an active protein targeting PGC. Also known as Pepsinogen II (PGII/PGC), Human Gastric Mucosa. Host: Human gastric mucosa.

Additional Details

NCBI/Uniprot data below describe general gene information for PGC. It may not necessarily be applicable to this product.

NCBI GI #
129796
NCBI GeneID
5225
NCBI Accession #
P20142.1
UniProt Primary Accession #
P20142
UniProt Secondary Accession #
Q5T3D7; Q5T3D8; B4DVZ3
UniProt Related Accession #
P20142
NCBI Official Full Name
Gastricsin
NCBI Official Synonym Full Names
progastricsin (pepsinogen C)
NCBI Official Symbol
PGC
NCBI Official Synonym Symbols
PEPC; PGII
UniProt Protein Name
Gastricsin
UniProt Synonym Protein Names
Pepsinogen C
Protein Family
Gastricsin
UniProt Gene Name
PGC
UniProt Entry Name
PEPC_HUMAN
NCBI Protein Information
gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II

NCBI Summary for PGC

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
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UniProt Comments for PGC

PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.23.3

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: extracellular space

Molecular Function: aspartic-type endopeptidase activity

Biological Process: digestion; proteolysis
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Research Articles on PGC

1. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PGC active protein

 Reference Product  PubMed Publications
 PGD active protein  >9 publications with PGC and PGD
 PCK1 active protein  >8 publications with PGC and PCK1
 ESR1 active protein  >1 publications with PGC and ESR1
 PCK2 active protein  >1 publications with PGC and PCK2

Diseases associated with PGC active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >265 publications with PGC and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >254 publications with PGC and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >236 publications with PGC and Disease Models, Animal
 Inflammation Antibodies  >200 publications with PGC and Inflammation
 Fatty Liver Antibodies  >185 publications with PGC and Fatty Liver
 Liver Diseases Antibodies  >147 publications with PGC and Liver Diseases
 Heart Diseases Antibodies  >147 publications with PGC and Heart Diseases
 Hypertrophy Antibodies  >113 publications with PGC and Hypertrophy
 Atrophy Antibodies  >108 publications with PGC and Atrophy
 Necrosis Antibodies  >107 publications with PGC and Necrosis

Organs/Tissues associated with PGC active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >525 publications with PGC and Liver
 Heart Antibodies  >357 publications with PGC and Heart
 Brain Antibodies  >289 publications with PGC and Brain
 Connective Tissue Antibodies  >224 publications with PGC and Connective Tissue
 Stomach Antibodies  >83 publications with PGC and Stomach
 Pancreas Antibodies  >54 publications with PGC and Pancreas
 Lung Antibodies  >44 publications with PGC and Lung
 Prostate Antibodies  >15 publications with PGC and Prostate
 Esophagus Antibodies  >4 publications with PGC and Esophagus
 Uncharacterized Tissue Antibodies  >1 publications with PGC and Uncharacterized Tissue
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