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HDAC11 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750075

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle… More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HDAC11/Histone Deacetylase 11, Monoclonal Antibody
Full Product Name
Anti-HDAC11/Histone Deacetylase 11 Rabbit Monoclonal Antibody
Product Gene Name
anti-HDAC11 antibody
Product Synonym Names
Histone deacetylase 11; HD11; 3.5.1.98; HDAC11
Clonality
Monoclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity-chromatography
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
39183 MW
OMIM
AK025426 mRNA
3D Structure
ModBase 3D Structure for Q96DB2
Immunogen
A synthesized peptide derived from human HDAC11
Subcellular Localization
Nucleus. Predominantly nuclear.
Tissue Specificity
Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Product Categories/Family for anti-HDAC11 antibody

Epigenetics and Nuclear Signaling; Chromatin Modifying Enzymes; Acetylation; Stem Cells; Signaling Pathways; wnt; HDACS; Epigenetics and Nuclear Signaling; class i
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-HDAC11 antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-HDAC11 antibody
WB: 1:1000-1:2000
IP: 1:50

Western Blot (WB) of anti-HDAC11 antibody

Western blot analysis of HDAC11 expression in (1) Jurkat cell lysate;(2) MCF7 cell lysate (MBS1750075).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-HDAC11 monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for HDAC11
Rabbit Anti-HDAC11 Monoclonal Antibody – Cat# MBS1750075

Other Notes

Small volumes of anti-HDAC11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDAC11 purchase

MBS1750075 is an antibody targeting HDAC11. Also known as Anti-HDAC11/Histone Deacetylase 11 Rabbit Monoclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HDAC11. It may not necessarily be applicable to this product.

NCBI GI #
209862883
NCBI GeneID
79885
NCBI Accession #
NP_001129513.1
UniProt Primary Accession #
Q96DB2
UniProt Secondary Accession #
Q9H6I7; Q9H6X3; Q9NTC9; B4DDK1
UniProt Related Accession #
Q96DB2
GenBank Nucleotide #
NM_001136041.2
NCBI Official Full Name
histone deacetylase 11 isoform 2
NCBI Official Synonym Full Names
histone deacetylase 11
NCBI Official Symbol
HDAC11
NCBI Official Synonym Symbols
HD11
UniProt Protein Name
Histone deacetylase 11
Protein Family
Histone deacetylase
UniProt Gene Name
HDAC11
UniProt Synonym Gene Names
HD11
NCBI Protein Information
histone deacetylase 11

NCBI Summary for HDAC11

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

Research Articles on HDAC11

1. Our study identified a group of cell cycle-promoting genes regulated by HDAC11.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HDAC11 antibody

 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By NOTCH Pathway antibodies  Signaling By NOTCH Pathway Diagram

Diseases associated with anti-HDAC11 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with HDAC11 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with HDAC11 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >4 publications with HDAC11 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >3 publications with HDAC11 and Neoplasms, Experimental
 Necrosis Antibodies  >3 publications with HDAC11 and Necrosis
 Kidney Diseases Antibodies  >2 publications with HDAC11 and Kidney Diseases
 Ovarian Diseases Antibodies  >2 publications with HDAC11 and Ovarian Diseases
 Breast Neoplasms Antibodies  >2 publications with HDAC11 and Breast Neoplasms
 Neurobehavioral Manifestations Antibodies  >1 publications with HDAC11 and Neurobehavioral Manifestations
 Fibrosis Antibodies  >1 publications with HDAC11 and Fibrosis

Organs/Tissues associated with anti-HDAC11 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with HDAC11 and Brain
 Nerve Antibodies  >4 publications with HDAC11 and Nerve
 Lung Antibodies  >3 publications with HDAC11 and Lung
 Kidney Antibodies  >3 publications with HDAC11 and Kidney
 Liver Antibodies  >3 publications with HDAC11 and Liver
 Heart Antibodies  >2 publications with HDAC11 and Heart
 Thyroid Antibodies  >2 publications with HDAC11 and Thyroid
 Prostate Antibodies  >2 publications with HDAC11 and Prostate
 Eye Antibodies  >2 publications with HDAC11 and Eye
 Testis Antibodies  >2 publications with HDAC11 and Testis
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