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TGN46 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750080

MBS1750080 is an antibody targeting TGN46. Also known as Anti-TGN46 Rabbit Monoclonal Antibody. Reactive in Human. Host: Rabbit. May be involved in regulating membrane traffic to and from trans-Golgi network. More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TGN46, Monoclonal Antibody
Full Product Name
Anti-TGN46 Rabbit Monoclonal Antibody
Product Gene Name
anti-TGN46 antibody
Product Synonym Gene Name
TGOLN2
Product Synonym Names
Trans-Golgi network integral membrane protein 2; TGN38 homolog; TGN46; TGN48; Trans-Golgi network protein TGN51; TGOLN2; TGN46; TGN51
Clonality
Monoclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity-chromatography
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
51113 MW
3D Structure
ModBase 3D Structure for O43493
Immunogen
A synthesized peptide derived from human TGN46
Subcellular Localization
Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single- pass type I membrane protein. Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes.
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Product Categories/Family for anti-TGN46 antibody

Tags & Cell Markers; Subcellular Markers; organelles; golgi
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TGN46 antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-TGN46 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IP: 1:50

Western Blot (WB) of anti-TGN46 antibody

Western blot analysis of TGN46 expression in HeLa cell lysate (MBS1750080).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TGOLN2 monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for TGOLN2
Rabbit Anti-TGN46 Monoclonal Antibody – Cat# MBS1750080

Other Notes

Small volumes of anti-TGN46 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TGN46. It may not necessarily be applicable to this product.

NCBI GI #
332205947
NCBI GeneID
10618
NCBI Accession #
NP_001193769.1
UniProt Primary Accession #
O43493
UniProt Secondary Accession #
O15282; O43492; O43499; O43500; O43501; Q53G68; Q53GV2; B2R686; B8ZZ88; D6W5K3; F8WBK2
UniProt Related Accession #
O43493
GenBank Nucleotide #
NM_001206840.1
NCBI Official Full Name
trans-Golgi network integral membrane protein 2 isoform 2
NCBI Official Synonym Full Names
trans-golgi network protein 2
NCBI Official Symbol
TGOLN2
NCBI Official Synonym Symbols
TGN38; TGN46; TGN48; TGN51; TTGN2
UniProt Protein Name
Trans-Golgi network integral membrane protein 2
UniProt Synonym Protein Names
TGN38 homolog; TGN46; TGN48; Trans-Golgi network protein TGN51
Protein Family
Trans-Golgi network integral membrane protein
UniProt Gene Name
TGOLN2
UniProt Synonym Gene Names
TGN46; TGN51
NCBI Protein Information
trans-Golgi network integral membrane protein 2

NCBI Summary for TGN46

This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
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UniProt Comments for TGN46

May be involved in regulating membrane traffic to and from trans-Golgi network.

Research Articles on TGN46

1. These results indicate that hepatitis E virus (HEV)forms membrane-associated particles in the cytoplasm, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TGN46 antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-TGN46 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >7 publications with TGN46 and Brain Diseases
 Neoplasms Antibodies  >6 publications with TGN46 and Neoplasms
 Disease Models, Animal Antibodies  >4 publications with TGN46 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >3 publications with TGN46 and Cardiovascular Diseases
 Lung Diseases Antibodies  >2 publications with TGN46 and Lung Diseases
 Inflammation Antibodies  >2 publications with TGN46 and Inflammation
 Skin Diseases Antibodies  >1 publications with TGN46 and Skin Diseases
 Movement Disorders Antibodies  >1 publications with TGN46 and Movement Disorders
 Cell Transformation, Neoplastic Antibodies  >1 publications with TGN46 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >1 publications with TGN46 and Liver Diseases

Organs/Tissues associated with anti-TGN46 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with TGN46 and Brain
 Nerve Antibodies  >16 publications with TGN46 and Nerve
 Kidney Antibodies  >12 publications with TGN46 and Kidney
 Liver Antibodies  >6 publications with TGN46 and Liver
 Blood Antibodies  >5 publications with TGN46 and Blood
 Muscle Antibodies  >4 publications with TGN46 and Muscle
 Heart Antibodies  >4 publications with TGN46 and Heart
 Skin Antibodies  >2 publications with TGN46 and Skin
 Lung Antibodies  >2 publications with TGN46 and Lung
 Vascular Antibodies  >2 publications with TGN46 and Vascular
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