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CD80 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750348

Description: Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD80, Polyclonal Antibody
Full Product Name
Anti-CD80 antibody
Product Gene Name
anti-CD80 antibody
Product Synonym Names
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD80; CD80; CD28LG; CD28LG1; LAB7
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
No cross reactivity with other proteins.
Form/Format
Lyophilized
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
18,761 Da
OMIM
M27533 mRNA
3D Structure
ModBase 3D Structure for P33681
Immunogen
E Coli-derived human CD80 recombinant protein (Position: V35-L244).
Subcellular Localization
Membrane; Single-pass type I membrane protein.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD80 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CD80 antibody
Immunohistochemistry (Paraffin-embedded Section): 0.5-1mug/ml
Direct ELISA: 0.1-0.5mug/ml

Immunohistochemistry (IHC) of anti-CD80 antibody

Figure 1. IHC analysis of CD80 using anti-CD80 antibody (MBS1750348).
CD80 was detected in paraffin-embedded section of human tonsil tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-CD80 Antibody (MBS1750348) overnight at 4 degree C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37 degree C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Rabbit Anti-CD80 Polyclonal Antibody – Cat# MBS1750348

Immunohistochemistry (IHC) of anti-CD80 antibody

Figure 2. IHC analysis of CD80 using anti-CD80 antibody (MBS1750348).
CD80 was detected in paraffin-embedded section of rat spleen tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-CD80 Antibody (MBS1750348) overnight at 4 degree C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37 degree C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Rabbit Anti-CD80 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1750348

Other Notes

Small volumes of anti-CD80 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD80 purchase

MBS1750348 is an antibody targeting CD80. Reactive in Human, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD80. It may not necessarily be applicable to this product.

NCBI GI #
4885123
NCBI GeneID
941
NCBI Accession #
NP_005182.1
UniProt Primary Accession #
P33681
UniProt Secondary Accession #
Q5DTA9; Q5DTB0
UniProt Related Accession #
P33681
GenBank Nucleotide #
NM_005191.3
NCBI Official Full Name
T-lymphocyte activation antigen CD80
NCBI Official Synonym Full Names
CD80 molecule
NCBI Official Symbol
CD80
NCBI Official Synonym Symbols
B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
UniProt Protein Name
T-lymphocyte activation antigen CD80
UniProt Synonym Protein Names
Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
Protein Family
T-lymphocyte activation antigen
UniProt Gene Name
CD80
UniProt Synonym Gene Names
CD28LG; CD28LG1; LAB7; B7
NCBI Protein Information
T-lymphocyte activation antigen CD80

NCBI Summary for CD80

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
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UniProt Comments for CD80

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

Research Articles on CD80

1. The rs1915087 (C>T), rs6804441 (A>G) and rs41271391 (G>T) of B7 antigens were suspected as the factors associated with reduced risk of recurrent spontaneous abortion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD80 antibody

 Reference Product  PubMed Publications
 CD86 antibody  >4733 publications with CD80 and CD86
 CD4 antibody  >2127 publications with CD80 and CD4
 CD28 antibody  >1813 publications with CD80 and CD28
 CTLA4 antibody  >1017 publications with CD80 and CTLA4
 ICAM1 antibody  >415 publications with CD80 and ICAM1
 PRF1 antibody  >62 publications with CD80 and PRF1
 IFNG antibody  >6 publications with CD80 and IFNG
 CSF2 antibody  >2 publications with CD80 and CSF2

Pathways associated with anti-CD80 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram

Diseases associated with anti-CD80 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1113 publications with CD80 and Necrosis
 Inflammation Antibodies  >753 publications with CD80 and Inflammation
 Neoplasms, Experimental Antibodies  >382 publications with CD80 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >344 publications with CD80 and Nervous System Diseases
 Lung Diseases Antibodies  >305 publications with CD80 and Lung Diseases
 Liver Diseases Antibodies  >224 publications with CD80 and Liver Diseases
 Kidney Diseases Antibodies  >156 publications with CD80 and Kidney Diseases
 Lung Neoplasms Antibodies  >110 publications with CD80 and Lung Neoplasms
 Liver Neoplasms Antibodies  >105 publications with CD80 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >82 publications with CD80 and Neoplasm Metastasis

Organs/Tissues associated with anti-CD80 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5942 publications with CD80 and Blood
 Lymph Node Antibodies  >580 publications with CD80 and Lymph Node
 Lung Antibodies  >419 publications with CD80 and Lung
 Thymus Antibodies  >177 publications with CD80 and Thymus
 Tonsil Antibodies  >39 publications with CD80 and Tonsil
 Connective Tissue Antibodies  >34 publications with CD80 and Connective Tissue
 Mammary Gland Antibodies  >4 publications with CD80 and Mammary Gland
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