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AGRP/ART Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750364

Description: Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. In humans, the agouti-related peptide is encoded by the AGRP gene. This gene encodes an antagonist of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
AGRP/Art, Polyclonal Antibody
Full Product Name
Anti-AGRP/Art Picoband antibody
Product Gene Name
anti-AGRP/Art antibody
Product Synonym Names
Agouti-related protein; Agrp; Agrt; Art
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
No cross reactivity with other proteins.
Form/Format
Lyophilized
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
14,432 Da
3D Structure
ModBase 3D Structure for P56473
Immunogen
E Coli-derived mouse AGRP recombinant protein (Position: S82-T131).
Subcellular Localization
Secreted.
Tissue Specificity
Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Product Categories/Family for anti-AGRP/Art antibody

Signal Transduction; Signaling Pathway; Calcium Signaling; Neuroscience; Neurology Process; Metabolism; endocrine system; hypothalamic pituitary adrenal axis; Cardiovascular; Lipids/Lipoproteins; Fatty Acids; Metabolism; Pathways and Processes; Metabolic
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-AGRP/Art antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-AGRP/Art antibody
Immunohistochemistry (Paraffin-embedded Section): 0.5-1mug/ml
Direct ELISA: 0.1-0.5mug/ml

Immunohistochemistry (IHC) of anti-AGRP/Art antibody

Figure 1. IHC analysis of AGRP using anti-AGRP antibody (MBS1750364).
AGRP was detected in paraffin-embedded section of mouse lung tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-AGRP Antibody (MBS1750364) overnight at 4 degree C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37 degree C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Rabbit Anti-AGRP/ART Polyclonal Antibody – Cat# MBS1750364

Immunohistochemistry (IHC) of anti-AGRP/Art antibody

Figure 2. IHC analysis of AGRP using anti-AGRP antibody (MBS1750364).
AGRP was detected in paraffin-embedded section of rat lung tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-AGRP Antibody (MBS1750364) overnight at 4 degree C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37 degree C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Rabbit Anti-AGRP/ART Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1750364

Immunohistochemistry (IHC) of anti-AGRP/Art antibody

Figure 3. IHC analysis of AGRP using anti-AGRP antibody (MBS1750364).
AGRP was detected in paraffin-embedded section of rat testis tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-AGRP Antibody (MBS1750364) overnight at 4 degree C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37 degree C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
Rabbit Anti-AGRP/ART Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1750364

Other Notes

Small volumes of anti-AGRP/Art antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGRP/Art purchase

MBS1750364 is an antibody targeting AGRP/Art. Also known as Anti-AGRP/Art Picoband antibody. Reactive in Human, Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AGRP/Art. It may not necessarily be applicable to this product.

NCBI GI #
424036681
NCBI GeneID
11604
NCBI Accession #
NP_001258735.1
UniProt Primary Accession #
P56473
UniProt Secondary Accession #
O35967
UniProt Related Accession #
P56473
GenBank Nucleotide #
NM_001271806.1
NCBI Official Full Name
agouti-related protein
NCBI Official Synonym Full Names
agouti related neuropeptide
NCBI Official Symbol
Agrp
NCBI Official Synonym Symbols
Art; Agrt
UniProt Protein Name
Agouti-related protein
UniProt Gene Name
Agrp
UniProt Synonym Gene Names
Agrt; Art
NCBI Protein Information
agouti-related protein

NCBI Summary for AGRP/Art

This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]

UniProt Comments for AGRP/Art

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity (). It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner ().
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Research Articles on AGRP/Art

1. POMC and AgRP neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1(ARC) neurons in male mice

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AGRP/Art antibody

 Reference Product  PubMed Publications
 Pomc antibody  >669 publications with AGRP/Art and Pomc
 Mc4r antibody  >153 publications with AGRP/Art and Mc4r
 Mc3r antibody  >71 publications with AGRP/Art and Mc3r
 Fos antibody  >48 publications with AGRP/Art and Fos
 Trh antibody  >33 publications with AGRP/Art and Trh
 Foxo1 antibody  >22 publications with AGRP/Art and Foxo1
 Lep antibody  >15 publications with AGRP/Art and Lep
 Mc5r antibody  >12 publications with AGRP/Art and Mc5r
 Mc2r antibody  >4 publications with AGRP/Art and Mc2r

Pathways associated with anti-AGRP/Art antibody

 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Genes Pathway antibodies  Adipogenesis Genes Pathway Diagram

Diseases associated with anti-AGRP/Art antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >459 publications with AGRP/Art and Obesity
 Weight Gain Antibodies  >140 publications with AGRP/Art and Weight Gain
 Weight Loss Antibodies  >109 publications with AGRP/Art and Weight Loss
 Insulin Resistance Antibodies  >73 publications with AGRP/Art and Insulin Resistance
 Disease Models, Animal Antibodies  >64 publications with AGRP/Art and Disease Models, Animal
 Diabetes Mellitus Antibodies  >51 publications with AGRP/Art and Diabetes Mellitus
 Hyperinsulinism Antibodies  >34 publications with AGRP/Art and Hyperinsulinism
 Inflammation Antibodies  >31 publications with AGRP/Art and Inflammation
 Hyperglycemia Antibodies  >30 publications with AGRP/Art and Hyperglycemia
 Glucose Intolerance Antibodies  >15 publications with AGRP/Art and Glucose Intolerance

Organs/Tissues associated with anti-AGRP/Art antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >822 publications with AGRP/Art and Brain
 Eye Antibodies  >7 publications with AGRP/Art and Eye
 Thymus Antibodies  >1 publications with AGRP/Art and Thymus
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