Rabbit Anti-FOXP2 Polyclonal Antibody – Cat# MBS1750620

Figure 1. Western blot analysis of FOXP2 using anti-FOXP2 antibody (MBS1750620).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: rat brain tissue lysate,
Lane 2: mouse brain tissue lysate,
Lane 3: human SK-OV-3 whole Cell lysate.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-FOXP2 antigen affinity purified polyclonal antibody at 0.5ug/mL overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for FOXP2 at approximately 90KD. The expected band size for FOXP2 is at 80KD.

FOXP2 Antibody – Rabbit Polyclonal

Name: FOXP2 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1750620
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750620

Description: Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FOXP2, Polyclonal Antibody

Full Product Name

Anti-FOXP2 Picoband Antibody

Product Gene Name

anti-FOXP2 antibody

Product Synonym Names

Forkhead box protein P2; CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein; FOXP2; CAGH44; TNRC10

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat
No cross reactivity with other proteins.

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified

Concentration

Add 0.2ml of distilled water will yield a concentration of 500ug/ml. (lot specific)

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

79919 MW

OMIM

AF337817 mRNA

3D Structure

ModBase 3D Structure for O15409

Immunogen

E Coli-derived human FOXP2 recombinant protein (Position: L637-E715). Human FOXP2 shares 100% amino acid (aa) sequence identity with both mouse and rat FOXP2.

Subcellular Localization

Nucleus.

Tissue Specificity

Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Product Categories/Family for anti-FOXP2 antibody

Epigenetics and Nuclear Signaling; Transcription; Domain Families; Forkhead Box; Epigenetics and Nuclear Signaling; foxp

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-FOXP2 antibody

Western Blot (WB)

Application Notes for anti-FOXP2 antibody

WB: 0.1-0.5mug/ml

Other Notes

Small volumes of anti-FOXP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXP2 purchase

MBS1750620 is an antibody targeting FOXP2. Also known as Anti-FOXP2 Picoband Antibody. Reactive in Human, Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXP2. It may not necessarily be applicable to this product.

NCBI GI #

289666732

NCBI GeneID

93986

NCBI Accession #

NP_001166237.1

UniProt Primary Accession #

O15409

UniProt Secondary Accession #

Q6ZND1; Q75MJ3; Q8IZE0; Q8N0W2; Q8N6B7; Q8N6B8; Q8NFQ1; A0AUV6; A4D0U8; A6NNW4; B4DLD9

UniProt Related Accession #

O15409

GenBank Nucleotide #

NM_001172766.2

NCBI Official Full Name

forkhead box protein P2 isoform V

NCBI Official Synonym Full Names

forkhead box P2

NCBI Official Symbol

FOXP2

NCBI Official Synonym Symbols

SPCH1; CAGH44; TNRC10

UniProt Protein Name

Forkhead box protein P2

UniProt Synonym Protein Names

CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein

Protein Family

Forkhead box protein

UniProt Gene Name

FOXP2

UniProt Synonym Gene Names

CAGH44; TNRC10

NCBI Protein Information

forkhead box protein P2

NCBI Summary for FOXP2

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

UniProt Comments for FOXP2

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

Research Articles on FOXP2

1. FOXP2 frontal cortex expression abnormalities were identified in Frontotemporal Degeneration patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FOXP2 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>112 publications with FOXP2 and Nervous System Diseases
Neurobehavioral Manifestations Antibodies	>106 publications with FOXP2 and Neurobehavioral Manifestations
Learning Disorders Antibodies	>35 publications with FOXP2 and Learning Disorders
Cognition Disorders Antibodies	>21 publications with FOXP2 and Cognition Disorders
Brain Diseases Antibodies	>21 publications with FOXP2 and Brain Diseases
Autistic Disorder Antibodies	>21 publications with FOXP2 and Autistic Disorder
SPEECH-LANGUAGE DISORDER 1 Antibodies	>14 publications with FOXP2 and SPEECH-LANGUAGE DISORDER 1
Apraxias Antibodies	>14 publications with FOXP2 and Apraxias
Congenital Abnormalities Antibodies	>12 publications with FOXP2 and Congenital Abnormalities
Disease Models, Animal Antibodies	>9 publications with FOXP2 and Disease Models, Animal

Organs/Tissues associated with anti-FOXP2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>188 publications with FOXP2 and Brain
Nerve Antibodies	>50 publications with FOXP2 and Nerve
Lung Antibodies	>17 publications with FOXP2 and Lung
Embryonic Tissue Antibodies	>16 publications with FOXP2 and Embryonic Tissue
Eye Antibodies	>8 publications with FOXP2 and Eye
Bone Antibodies	>6 publications with FOXP2 and Bone
Muscle Antibodies	>6 publications with FOXP2 and Muscle
Skin Antibodies	>4 publications with FOXP2 and Skin
Intestine Antibodies	>3 publications with FOXP2 and Intestine
Mouth Antibodies	>3 publications with FOXP2 and Mouth