Rabbit Anti-PROS1 Polyclonal Antibody – Cat# MBS1750671

Figure 1. Western blot analysis of Protein S using anti-Protein S antibody (MBS1750671).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: human HepG2 whole cell lysates.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Protein S antigen affinity purified polyclonal antibody at 0.5ug/mL overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for Protein S at approximately 75KD. The expected band size for Protein S is at 75KD.

Protein S (PROS1) Antibody – Rabbit Polyclonal

Name: PROS1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1750671
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750671

Description: This PROS1 gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Protein S (PROS1), Polyclonal Antibody

Full Product Name

Anti-Protein S Picoband antibody

Product Gene Name

anti-PROS1 antibody

Product Synonym Names

Vitamin K-dependent protein S; PROS1; PROS

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human
No cross reactivity with other proteins.

Form/Format

Lyophilized

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

75,123 Da

OMIM

Y00692 mRNA

3D Structure

ModBase 3D Structure for P07225

Immunogen

E Coli-derived human Protein S recombinant protein (Position: L291-S676).

Subcellular Localization

Secreted.

Tissue Specificity

Plasma.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-PROS1 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-PROS1 antibody

WB: 0.1-0.5mug/ml
Direct ELISA: 0.1-0.5mug/ml

Other Notes

Small volumes of anti-PROS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PROS1 purchase

MBS1750671 is an antibody targeting PROS1. Also known as Anti-Protein S Picoband antibody. Reactive in Human
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PROS1. It may not necessarily be applicable to this product.

NCBI GI #

192447438

NCBI GeneID

5627

NCBI Accession #

NP_000304.2

UniProt Primary Accession #

P07225

UniProt Secondary Accession #

Q15518; Q7Z715; Q9UCZ8; A8KAC9; D3DN28

UniProt Related Accession #

P07225

GenBank Nucleotide #

NM_000313.3

NCBI Official Full Name

vitamin K-dependent protein S isoform 2 preproprotein

NCBI Official Synonym Full Names

protein S

NCBI Official Symbol

PROS1

NCBI Official Synonym Symbols

PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6

UniProt Protein Name

Vitamin K-dependent protein S

Protein Family

Proline--tRNA ligase

UniProt Gene Name

PROS1

UniProt Synonym Gene Names

PROS

NCBI Protein Information

vitamin K-dependent protein S

NCBI Summary for PROS1

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

UniProt Comments for PROS1

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

Research Articles on PROS1

1. Taken together, our gain-of-function, loss-of-function analyses suggest that PROS may facilitate cell proliferation and promote castration resistance in human castration-resistant PCa-like cells via its apoptosis-regulating property.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PROS1 antibody

Reference Product	PubMed Publications
PROC antibody	>4 publications with PROS1 and PROC
C4BPB antibody	>2 publications with PROS1 and C4BPB
C4BPA antibody	>2 publications with PROS1 and C4BPA
TYRO3 antibody	>1 publications with PROS1 and TYRO3

Pathways associated with anti-PROS1 antibody

Products by Pathway	Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Common Pathway antibodies	Common Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Gamma-carboxylation Of Protein Precursors Pathway antibodies	Gamma-carboxylation Of Protein Precursors Pathway Diagram
Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies	Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with anti-PROS1 antibody

Disease Name	Pubmed Publications
Blood Coagulation Disorders Antibodies	>62 publications with PROS1 and Blood Coagulation Disorders
Thrombosis Antibodies	>50 publications with PROS1 and Thrombosis
Cardiovascular Diseases Antibodies	>37 publications with PROS1 and Cardiovascular Diseases
Vascular Diseases Antibodies	>37 publications with PROS1 and Vascular Diseases
Venous Thrombosis Antibodies	>28 publications with PROS1 and Venous Thrombosis
Thromboembolism Antibodies	>10 publications with PROS1 and Thromboembolism
Venous Thromboembolism Antibodies	>9 publications with PROS1 and Venous Thromboembolism
Neoplasms Antibodies	>7 publications with PROS1 and Neoplasms
THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT Antibodies	>4 publications with PROS1 and THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT
Inflammation Antibodies	>3 publications with PROS1 and Inflammation

Organs/Tissues associated with anti-PROS1 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>8 publications with PROS1 and Vascular
Liver Antibodies	>5 publications with PROS1 and Liver
Thyroid Antibodies	>2 publications with PROS1 and Thyroid
Kidney Antibodies	>2 publications with PROS1 and Kidney
Brain Antibodies	>2 publications with PROS1 and Brain
Heart Antibodies	>1 publications with PROS1 and Heart
Lung Antibodies	>1 publications with PROS1 and Lung
Muscle Antibodies	>1 publications with PROS1 and Muscle
Intestine Antibodies	>1 publications with PROS1 and Intestine