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TL1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750765

Description: Vascular endothelial growth inhibitor (VEGI), also known as TNF-like ligand 1A (TL1A) and TNF superfamily member 15 (TNFSF15), is protein that in humans is encoded by the TNFSF15 gene. The protein encoded by this gene is a cytokine that belongs… More details

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Product Overview

Online Datasheet in PDF
Product Name
TL1A, Polyclonal Antibody
Full Product Name
Anti-TL1A Picoband antibody
Product Gene Name
anti-TL1A antibody
Product Synonym Gene Name
TNFSF15
Product Synonym Names
Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor; Tumor necrosis factor ligand superfamily member 15; membrane form; Tumor necrosis factor ligand superfamily member 15; secreted form; TNFSF15; TL1; VEGI
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
No cross reactivity with other proteins.
Form/Format
Lyophilized
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
20,131 Da
OMIM
AF039390 mRNA
3D Structure
ModBase 3D Structure for O95150
Immunogen
E Coli-derived human TL1A recombinant protein (Position: L72-T244).
Subcellular Localization
Membrane.
Tissue Specificity
Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Product Categories/Family for anti-TL1A antibody

Cardiovascular; Angiogenesis; Inhibitors; Immunology; Innate Immunity; Cytokines; TNF Superfamily
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TL1A antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TL1A antibody
WB: 0.1-0.5mug/ml
ELISA(Cap): 1-5mug/ml

Western Blot (WB) of anti-TL1A antibody

Figure 1. Western blot analysis of TL1A using anti-TL1A antibody (MBS1750765).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: rat liver tissue lysates,
Lane 2: rat kidney tissue lysates,
Lane 3: mouse kidney tissue lysates.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-TL1A antigen affinity purified polyclonal antibody at 0.5ug/mL overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for TL1A at approximately 28KD. The expected band size for TL1A is at 28KD.
Rabbit Anti-TL1A Polyclonal Antibody – Cat# MBS1750765

Other Notes

Small volumes of anti-TL1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TL1A purchase

MBS1750765 is an antibody targeting TL1A. Also known as Anti-TL1A Picoband antibody. Reactive in Human, Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TL1A. It may not necessarily be applicable to this product.

NCBI GI #
324072728
NCBI GeneID
9966
NCBI Accession #
NP_001191273.1
UniProt Primary Accession #
O95150
UniProt Secondary Accession #
Q3SX69; Q5VJK8; Q5VWH1; Q8NFE9
UniProt Related Accession #
O95150
GenBank Nucleotide #
NM_001204344.1
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 15 isoform VEGI-192
NCBI Official Synonym Full Names
TNF superfamily member 15
NCBI Official Symbol
TNFSF15
NCBI Official Synonym Symbols
TL1; TL1A; VEGI; TNLG1B; VEGI192A
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 15
UniProt Synonym Protein Names
TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor
Protein Family
U8-barytoxin
UniProt Gene Name
TNFSF15
UniProt Synonym Gene Names
TL1; VEGI
NCBI Protein Information
tumor necrosis factor ligand superfamily member 15

NCBI Summary for TL1A

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
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UniProt Comments for TL1A

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Research Articles on TL1A

1. the DR3/TL1A pathway directly enhances human OC formation and resorptive activity, controlling expression and activation of CCL3 and MMP-9.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TL1A antibody

 Reference Product  PubMed Publications
 TNFRSF25 antibody  >28 publications with TL1A and TNFRSF25
 TNFRSF6B antibody  >13 publications with TL1A and TNFRSF6B

Pathways associated with anti-TL1A antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram

Diseases associated with anti-TL1A antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >128 publications with TL1A and Necrosis
 Colitis Antibodies  >23 publications with TL1A and Colitis
 Colitis, Ulcerative Antibodies  >19 publications with TL1A and Colitis, Ulcerative
 Atherosclerosis Antibodies  >5 publications with TL1A and Atherosclerosis
 Liver Diseases Antibodies  >4 publications with TL1A and Liver Diseases
 Breast Neoplasms Antibodies  >4 publications with TL1A and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with TL1A and Cardiovascular Diseases
 Fibrosis Antibodies  >3 publications with TL1A and Fibrosis
 Hyperplasia Antibodies  >3 publications with TL1A and Hyperplasia
 Nervous System Diseases Antibodies  >2 publications with TL1A and Nervous System Diseases

Organs/Tissues associated with anti-TL1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with TL1A and Blood
 Intestine Antibodies  >15 publications with TL1A and Intestine
 Embryonic Tissue Antibodies  >10 publications with TL1A and Embryonic Tissue
 Lung Antibodies  >6 publications with TL1A and Lung
 Kidney Antibodies  >5 publications with TL1A and Kidney
 Brain Antibodies  >3 publications with TL1A and Brain
 Eye Antibodies  >2 publications with TL1A and Eye
 Testis Antibodies  >1 publications with TL1A and Testis
 Prostate Antibodies  >1 publications with TL1A and Prostate
 Thyroid Antibodies  >1 publications with TL1A and Thyroid
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