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BAFF Receptor (BAFF-R) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1750792

Description: Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), also known as BAFFR, is a protein in humans is encoded by the TNFRSF13C gene. The BAFFR gene is mapped to chromosome 22q13.1-q13.31. It has got 184 amino acid transmembrane… More details

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Product Overview

Online Datasheet in PDF
Product Name
BAFF Receptor (BAFF-R), Polyclonal Antibody
Full Product Name
Anti-BAFF Receptor Picoband antibody
Product Gene Name
anti-BAFF-R antibody
Product Synonym Gene Name
TNFRSF13C
Product Synonym Names
Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor; BLyS receptor 3; CD268; TNFRSF13C; BAFFR; BR3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
No cross reactivity with other proteins.
Form/Format
Lyophilized
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
18,935 Da
OMIM
AF373846 mRNA
3D Structure
ModBase 3D Structure for Q96RJ3
Immunogen
E Coli-derived human BAFF Receptor recombinant protein (Position: M1-L78).
Subcellular Localization
Membrane; Single-pass type III membrane protein.
Tissue Specificity
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-BAFF-R antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-BAFF-R antibody
WB: 0.1-0.5mug/ml
Direct ELISA: 0.1-0.5mug/ml

Western Blot (WB) of anti-BAFF-R antibody

Figure 1. Western blot analysis of BAFF Receptor using anti-BAFF Receptor antibody (MBS1750792).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
Lane 1: human Jurkat whole cell lysates,
Lane 2: rat spleen tissue lysates,
Lane 3: rat thymus tissue lysates,
Lane 4: mouse spleen tissue lysates,
Lane 5: mouse thymus tissue lysates.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-BAFF Receptor antigen affinity purified polyclonal antibody at 0.5ug/mL overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for BAFF Receptor at approximately 19KD. The expected band size for BAFF Receptor is at 19KD.
Rabbit Anti-BAFF-R Polyclonal Antibody – Cat# MBS1750792

Other Notes

Small volumes of anti-BAFF-R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAFF-R purchase

MBS1750792 is an antibody targeting BAFF-R. Also known as Anti-BAFF Receptor Picoband antibody. Reactive in Human, Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BAFF-R. It may not necessarily be applicable to this product.

NCBI GI #
16445027
NCBI GeneID
115650
NCBI Accession #
NP_443177.1
UniProt Primary Accession #
Q96RJ3
UniProt Related Accession #
Q96RJ3
GenBank Nucleotide #
NM_052945.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 13C
NCBI Official Synonym Full Names
TNF receptor superfamily member 13C
NCBI Official Symbol
TNFRSF13C
NCBI Official Synonym Symbols
BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 13C
UniProt Synonym Protein Names
B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF13C
UniProt Synonym Gene Names
BAFFR; BR3; BAFF-R
NCBI Protein Information
tumor necrosis factor receptor superfamily member 13C

NCBI Summary for BAFF-R

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
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UniProt Comments for BAFF-R

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

Research Articles on BAFF-R

1. up-regulated expression in intractable temporal lobe epilepsy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BAFF-R antibody

 Reference Product  PubMed Publications
 TNFSF13B antibody  >121 publications with BAFF-R and TNFSF13B
 TNFRSF13B antibody  >55 publications with BAFF-R and TNFRSF13B
 TRAF3 antibody  >8 publications with BAFF-R and TRAF3
 PTPRC antibody  >1 publications with BAFF-R and PTPRC
 CXCR5 antibody  >1 publications with BAFF-R and CXCR5
 POU2AF1 antibody  >1 publications with BAFF-R and POU2AF1
 TRAF1 antibody  >1 publications with BAFF-R and TRAF1

Pathways associated with anti-BAFF-R antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram

Diseases associated with anti-BAFF-R antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >141 publications with BAFF-R and Necrosis
 Immune System Diseases Antibodies  >103 publications with BAFF-R and Immune System Diseases
 Inflammation Antibodies  >22 publications with BAFF-R and Inflammation
 Common Variable Immunodeficiency Antibodies  >11 publications with BAFF-R and Common Variable Immunodeficiency
 Kidney Diseases Antibodies  >7 publications with BAFF-R and Kidney Diseases
 Hyperplasia Antibodies  >6 publications with BAFF-R and Hyperplasia
 Atherosclerosis Antibodies  >4 publications with BAFF-R and Atherosclerosis
 Skin Diseases Antibodies  >4 publications with BAFF-R and Skin Diseases
 Demyelinating Diseases Antibodies  >4 publications with BAFF-R and Demyelinating Diseases
 Neoplasms, Experimental Antibodies  >3 publications with BAFF-R and Neoplasms, Experimental

Organs/Tissues associated with anti-BAFF-R antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >14 publications with BAFF-R and Lymph Node
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