Rabbit Anti-IBSP Polyclonal Antibody – Cat# MBS175104

Anti-Bone Sialoprotein antibody, MBS175104, IHC(P)
IHC(P): Human Osteosarcoma Tissue

Bone Sialoprotein (IBSP) Antibody – Rabbit Polyclonal

Name: IBSP Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS175104
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175104

Description: Rabbit IgG polyclonal antibody for Bone sialoprotein 2(IBSP) detection. Tested with WB, IHC-P in Human, Mouse, Rat.Background: BSP is also known as IBSP(integrin-binding sialoprotein). The protein encoded by this gene is a major structural… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Bone Sialoprotein (IBSP), Polyclonal Antibody

Full Product Name

Anti-Bone Sialoprotein antibody

Product Gene Name

anti-IBSP antibody

Product Synonym Names

Bone sialoprotein 2; integrin-binding sialoprotein; BNSP antibody; Bone sialoprotein 2 antibody; Bone sialoprotein 2 precursor antibody; Bone sialoprotein II antibody; bone sialoprotein II; bone sialoprotein antibody; BSP antibody; BSP II antibody; BSPII antibody; Cell binding sialoprotein antibody; Cell-binding sialoprotein antibody; IBSP antibody; Integrin binding sialoprotein antibody; Integrin binding sialoprotein(bone sialoprotein II) antibody; integrin binding sialoprotein(bone sialoprotein, bone sialoprotein II) antibody; Integrin-binding sialoprotein antibody; SIAL_HUMAN antibody; SPII antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

35,148 Da

OMIM

147563

3D Structure

ModBase 3D Structure for P21815

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Bone Sialoprotein (17-34aa FSMKNLHRRVKIEDSEEN), different from the related rat and mouse sequences by three amino acids.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-IBSP antibody

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Other Notes

Small volumes of anti-IBSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IBSP purchase

MBS175104 is an antibody targeting IBSP. Also known as Anti-Bone Sialoprotein antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IBSP. It may not necessarily be applicable to this product.

NCBI GI #

317373545

NCBI GeneID

3381

NCBI Accession #

P21815.4

UniProt Primary Accession #

P21815

UniProt Related Accession #

P21815

NCBI Official Full Name

Bone sialoprotein 2

NCBI Official Synonym Full Names

integrin-binding sialoprotein

NCBI Official Symbol

IBSP

NCBI Official Synonym Symbols

BSP; BNSP; SP-II; BSP-II

UniProt Protein Name

Bone sialoprotein 2

UniProt Synonym Protein Names

Bone sialoprotein II; BSP II; Cell-binding sialoprotein; Integrin-binding sialoprotein

Protein Family

Bone sialoprotein

UniProt Gene Name

IBSP

UniProt Synonym Gene Names

BNSP; BSP II

UniProt Entry Name

SIAL_HUMAN

NCBI Protein Information

bone sialoprotein 2; BSP II; bone sialoprotein II; cell-binding sialoprotein

NCBI Summary for IBSP

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

UniProt Comments for IBSP

Sialoprotein-2: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Protein type: Secreted, signal peptide; Secreted; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: extracellular space; membrane; extracellular region

Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; biomineral formation; cell adhesion

Research Articles on IBSP

1. Current evidence demonstrates that BSP and OPN, play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IBSP antibody

Reference Product	PubMed Publications
SPP1 antibody	>195 publications with IBSP and SPP1
FGF2 antibody	>26 publications with IBSP and FGF2
BGLAP antibody	>14 publications with IBSP and BGLAP
ITGA2B antibody	>1 publications with IBSP and ITGA2B
ITGB3 antibody	>1 publications with IBSP and ITGB3
ITGAV antibody	>1 publications with IBSP and ITGAV

Pathways associated with anti-IBSP antibody

Products by Pathway	Pathway Diagram
ECM Proteoglycans Pathway antibodies	ECM Proteoglycans Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Integrin Cell Surface Interactions Pathway antibodies	Integrin Cell Surface Interactions Pathway Diagram
Interleukin-11 Signaling Pathway antibodies	Interleukin-11 Signaling Pathway Diagram
Osteoblast Signaling Pathway antibodies	Osteoblast Signaling Pathway Diagram

Diseases associated with anti-IBSP antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>42 publications with IBSP and Breast Neoplasms
Neoplasm Metastasis Antibodies	>24 publications with IBSP and Neoplasm Metastasis
Kidney Diseases Antibodies	>14 publications with IBSP and Kidney Diseases
Neoplasms, Experimental Antibodies	>12 publications with IBSP and Neoplasms, Experimental
Prostatic Neoplasms Antibodies	>11 publications with IBSP and Prostatic Neoplasms
Inflammation Antibodies	>9 publications with IBSP and Inflammation
Lung Diseases Antibodies	>9 publications with IBSP and Lung Diseases
Necrosis Antibodies	>6 publications with IBSP and Necrosis
Neoplasm Invasiveness Antibodies	>6 publications with IBSP and Neoplasm Invasiveness
Nervous System Diseases Antibodies	>6 publications with IBSP and Nervous System Diseases

Organs/Tissues associated with anti-IBSP antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>667 publications with IBSP and Bone
Connective Tissue Antibodies	>186 publications with IBSP and Connective Tissue
Embryonic Tissue Antibodies	>38 publications with IBSP and Embryonic Tissue
Brain Antibodies	>7 publications with IBSP and Brain