• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Caveolin-3/CAV3 (CAV3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1751298

Description: Rabbit IgG polyclonal antibody for Caveolin-3/CAV3 detection. Tested with WB, IHC-P, Direct ELISA in Human; Mouse; Rat.Background: Caveolin-3 is a protein that in humans is encoded by the CAV3 gene. This gene encodes a caveolin family member,… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Caveolin-3/CAV3, Polyclonal Antibody
Full Product Name
Anti-Caveolin-3/CAV3 Antibody
Product Gene Name
anti-CAV3 antibody
Product Synonym Names
Caveolin-3; M-caveolin; CAV3; Caveolin 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
No cross reactivity with other proteins.
Form/Format
Lyophilized
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, store at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
Molecular Weight
17,259 Da
3D Structure
ModBase 3D Structure for P56539
Immunogen
E Coli-derived human Caveolin-3/CAV3 recombinant protein (Position: M1-D55).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500mug/ml.
Relevant Detection Systems
We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit for IHC(P).
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CAV3 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA)
Application Notes for anti-CAV3 antibody
WB: 0.1-0.5ug/ml
IHC-P: 0.5-1ug/ml
Direct ELISA: 0.1-0.5ug/ml
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested.

Product References and Citations for anti-CAV3 antibody

1. McNally EM, de Sá Moreira E, Duggan DJ, Bönnemann CG, Lisanti MP, Lidov HG, Vainzof M, Passos-Bueno MR, Hoffman EP, Zatz M, Kunkel LM (August 1998). "Caveolin-3 in muscular dystrophy". Hum Mol Genet. 7 (5): 871-7. 2. Minetti C, Sotgia F, Bruno C, Scartezzini P, Broda P, Bado M, Masetti E, Mazzocco M, Egeo A, Donati MA, Volonte D, Galbiati F, Cordone G, Bricarelli FD, Lisanti MP, Zara F (April 1998). "Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy". Nat Genet. 18 (4): 365-8.

Other Notes

Small volumes of anti-CAV3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAV3 purchase

MBS1751298 is an antibody targeting CAV3. Also known as Anti-Caveolin-3/CAV3 Antibody. Reactive in Human, Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CAV3. It may not necessarily be applicable to this product.

NCBI GI #
4502589
NCBI GeneID
859
NCBI Accession #
NP_001225.1
UniProt Primary Accession #
P56539
UniProt Secondary Accession #
Q3T1A4; A8K777
UniProt Related Accession #
P56539
GenBank Nucleotide #
NM_001234.4
NCBI Official Full Name
caveolin-3
NCBI Official Synonym Full Names
caveolin 3
NCBI Official Symbol
CAV3
NCBI Official Synonym Symbols
LQT9; MPDT; RMD2; VIP21; LGMD1C; VIP-21
UniProt Protein Name
Caveolin-3
UniProt Synonym Protein Names
M-caveolin
Protein Family
Caveolin
UniProt Gene Name
CAV3
NCBI Protein Information
caveolin-3

NCBI Summary for CAV3

This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CAV3

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564).
Show more

Research Articles on CAV3

1. T78M cav-3 induces complex modifications in ion channel function that ultimately alter membrane excitability and thus generate a susceptible substrate that, in concert with other structural alterations and/or genetic mutations, may become arrhythmogenic.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAV3 antibody

 Reference Product  PubMed Publications
 DYSF antibody  >14 publications with CAV3 and DYSF
 NOS3 antibody  >11 publications with CAV3 and NOS3
 DES antibody  >8 publications with CAV3 and DES
 NOS1 antibody  >7 publications with CAV3 and NOS1
 DMD antibody  >7 publications with CAV3 and DMD
 DAG1 antibody  >6 publications with CAV3 and DAG1
 TRIM72 antibody  >2 publications with CAV3 and TRIM72
 PFKM antibody  >1 publications with CAV3 and PFKM
 PDGFRA antibody  >1 publications with CAV3 and PDGFRA

Pathways associated with anti-CAV3 antibody

 Products by Pathway  Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 PDGFR-alpha Signaling Pathway antibodies  PDGFR-alpha Signaling Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram

Diseases associated with anti-CAV3 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >75 publications with CAV3 and Heart Diseases
 Pain Antibodies  >46 publications with CAV3 and Pain
 Muscular Dystrophies, Limb-Girdle Antibodies  >34 publications with CAV3 and Muscular Dystrophies, Limb-Girdle
 Arrhythmias, Cardiac Antibodies  >33 publications with CAV3 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >31 publications with CAV3 and Hypertrophy
 Cardiomegaly Antibodies  >20 publications with CAV3 and Cardiomegaly
 Heart Defects, Congenital Antibodies  >18 publications with CAV3 and Heart Defects, Congenital
 Hypertension Antibodies  >15 publications with CAV3 and Hypertension
 Inflammation Antibodies  >12 publications with CAV3 and Inflammation
 Cardiomyopathy, Hypertrophic Antibodies  >9 publications with CAV3 and Cardiomyopathy, Hypertrophic

Organs/Tissues associated with anti-CAV3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >286 publications with CAV3 and Muscle
 Embryonic Tissue Antibodies  >22 publications with CAV3 and Embryonic Tissue
 Prostate Antibodies  >5 publications with CAV3 and Prostate
 Connective Tissue Antibodies  >4 publications with CAV3 and Connective Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000