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CDA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1751358

Description: Rabbit IgG polyclonal antibody for CDA detection. Tested with WB, IHC-P in Human; Mouse; Rat.Background: Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene is mapped to 1p36.12. It encodes an enzyme involved in… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CDA, Polyclonal Antibody
Full Product Name
Anti-CDA Antibody
Product Gene Name
anti-CDA antibody
Product Synonym Names
Cytidine deaminase; Cytidine aminohydrolase; CDA; CDD
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen Affinity Purified
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
Molecular Weight
16,185 Da
3D Structure
ModBase 3D Structure for P32320
Immunogen
A synthetic peptide corresponding to a sequence of human CDA (MAQKRPACTLKPECVQQLLVCSQEAKK).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Relevant Detection Systems
It is recommended to use an Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC-P.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CDA antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CDA antibody
WB: 0.1-0.5 mug/ml
IHC-P: 0.5-1 mug/ml
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.

Product References and Citations for anti-CDA antibody

1. Demontis, S., Terao, M., Brivio, M., Zanotta, S., Bruschi, M., Garattini, E. Isolation and characterization of the gene coding for human cytidine deaminase. Biochim. Biophys. Acta 1443: 323-333, 1998. 2. Fitzgerald, S. M., Goyal, R. K., Osborne, W. R. A., Roy, J. D., Wilson, J. W., Ferrell, R. E. Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter. Hum. Genet. 119: 276-283, 2006. 3. Jahns-Streubel, G., Reuter, C., Auf der Landwehr, U., Unterhalt, M., Schleyer, E., Wormann, B., Buchner, T., Hiddemann, W. Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia. Blood 90: 1968-1976, 1997.

Other Notes

Small volumes of anti-CDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDA purchase

MBS1751358 is an antibody targeting CDA. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDA. It may not necessarily be applicable to this product.

NCBI GI #
11386157
NCBI GeneID
978
NCBI Accession #
NP_001776.1
UniProt Primary Accession #
P32320
UniProt Related Accession #
P32320
GenBank Nucleotide #
NM_001785.3
NCBI Official Full Name
cytidine deaminase
NCBI Official Synonym Full Names
cytidine deaminase
NCBI Official Symbol
CDA
NCBI Official Synonym Symbols
CDD
UniProt Protein Name
Cytidine deaminase
UniProt Synonym Protein Names
Cytidine aminohydrolase
Protein Family
Calcium-transporting ATPase
UniProt Gene Name
CDA
UniProt Synonym Gene Names
CDD
NCBI Protein Information
cytidine deaminase

NCBI Summary for CDA

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
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UniProt Comments for CDA

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Research Articles on CDA

1. The observed incomplete sister chromatid disjunction may be due to the accumulation of unreplicated DNA during mitosis in CDA-deficient cells, as reflected in the changes in centromeric DNA structure associated with the decrease in basal PARP-1 activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDA antibody

 Reference Product  PubMed Publications
 DCK antibody  >74 publications with CDA and DCK
 NT5C2 antibody  >4 publications with CDA and NT5C2
 PNP antibody  >2 publications with CDA and PNP

Pathways associated with anti-CDA antibody

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Salvage Reactions Pathway antibodies  Pyrimidine Salvage Reactions Pathway Diagram

Diseases associated with anti-CDA antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >263 publications with CDA and Anemia
 Anemia, Hemolytic Antibodies  >214 publications with CDA and Anemia, Hemolytic
 Neutropenia Antibodies  >93 publications with CDA and Neutropenia
 Nervous System Diseases Antibodies  >92 publications with CDA and Nervous System Diseases
 Bone Marrow Diseases Antibodies  >92 publications with CDA and Bone Marrow Diseases
 Thrombocytopenia Antibodies  >71 publications with CDA and Thrombocytopenia
 Lung Diseases Antibodies  >67 publications with CDA and Lung Diseases
 Carcinoma Antibodies  >56 publications with CDA and Carcinoma
 Gastrointestinal Diseases Antibodies  >41 publications with CDA and Gastrointestinal Diseases
 Neoplasms, Experimental Antibodies  >39 publications with CDA and Neoplasms, Experimental

Organs/Tissues associated with anti-CDA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >528 publications with CDA and Blood
 Bone Antibodies  >317 publications with CDA and Bone
 Bone Marrow Antibodies  >236 publications with CDA and Bone Marrow
 Brain Antibodies  >81 publications with CDA and Brain
 Liver Antibodies  >70 publications with CDA and Liver
 Skin Antibodies  >60 publications with CDA and Skin
 Kidney Antibodies  >54 publications with CDA and Kidney
 Lung Antibodies  >45 publications with CDA and Lung
 Spleen Antibodies  >30 publications with CDA and Spleen
 Eye Antibodies  >21 publications with CDA and Eye
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