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SRCIN1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1751511

Description: Rabbit IgG polyclonal antibody for SRCIN1 detection. Tested with WB, IHC-P, Direct ELISA in Human; Mouse; Rat.Background: Using yeast 2-hybrid analysis, protein pull-down assays, and mutation analysis, it is showed that the first coiled-coil… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SRCIN1, Polyclonal Antibody
Full Product Name
Anti-SRCIN1 Antibody
Product Gene Name
anti-SRCIN1 antibody
Product Synonym Names
SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p14 degree Cap; SRCIN1; KIAA1684; P140
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
No cross reactivity with other proteins.
Form/Format
Lyophilized
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, store at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
Molecular Weight
107,997 Da
3D Structure
ModBase 3D Structure for Q9C0H9
Immunogen
E Coli-derived human SRCIN1 recombinant protein (Position: E189-E287).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500mug/ml.
Relevant Detection Systems
We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit for IHC(P).
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SRCIN1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA)
Application Notes for anti-SRCIN1 antibody
WB: 0.1-0.5ug/ml
IHC-P: 0.5-1ug/ml
Direct ELISA: 0.1-0.5ug/ml
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested.

Product References and Citations for anti-SRCIN1 antibody

1. Chin, L.-S., Nugent, R. D., Raynor, M. C., Vavalle, J. P., Li, L. SNIP, a novel SNAP-25-interacting protein implicated in regulated exocytosis. J. Biol. Chem. 275: 1191-1200, 2000. 2. Nagase, T., Kikuno, R., Hattori, A., Kondo, Y., Okumura, K., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 347-355, 2000.

Other Notes

Small volumes of anti-SRCIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRCIN1 purchase

MBS1751511 is an antibody targeting SRCIN1. Reactive in Human, Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SRCIN1. It may not necessarily be applicable to this product.

NCBI GI #
115334682
NCBI GeneID
80725
NCBI Accession #
NP_079524.2
UniProt Primary Accession #
Q9C0H9
UniProt Secondary Accession #
Q75T46; Q8N4W8
UniProt Related Accession #
Q9C0H9
GenBank Nucleotide #
NM_025248.3
NCBI Official Full Name
SRC kinase signaling inhibitor 1
NCBI Official Synonym Full Names
SRC kinase signaling inhibitor 1
NCBI Official Symbol
SRCIN1
NCBI Official Synonym Symbols
P140; SNIP
UniProt Protein Name
SRC kinase signaling inhibitor 1
UniProt Synonym Protein Names
SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap
Protein Family
SRC kinase signaling inhibitor
UniProt Gene Name
SRCIN1
UniProt Synonym Gene Names
KIAA1684; P140; SNIP
NCBI Protein Information
SRC kinase signaling inhibitor 1

UniProt Comments for SRCIN1

Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
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Research Articles on SRCIN1

1. Data indicate that the major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SRCIN1 antibody

 Reference Product  PubMed Publications
 BCAR1 antibody  >1 publications with SRCIN1 and BCAR1
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