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CPAMD8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1751524

CPAMD8 belongs to the complement component-3 (C3; 120700)/alpha-2-macroglobulin (A2M; 103950) family of proteins, which are involved in innate immunity and damage control. The encoded protein is membrane-associated and proteolytically processed to generate… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CPAMD8, Polyclonal Antibody
Full Product Name
Anti-CPAMD8 Antibody
Product Gene Name
anti-CPAMD8 antibody
Product Synonym Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8; CPAMD8; KIAA1283; C3 and PZP like, alpha-2-macroglobulin domain containing 8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human; No cross reactivity with other proteins.
Form/Format
Lyophilized; Contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, store at 4 degree C for one month.
It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for Q8IZJ3
Immunogen
E Coli-derived human CPAMD8 recombinant protein (Position: R58-D234).
Reconstitution
0.2ml of distilled water will yield a concentration of 500mug/ml.
Relevant Detection Systems
We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (please inquire) for IHC(P).
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CPAMD8 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Direct ELISA (EIA)
Application Notes for anti-CPAMD8 antibody
WB: 0.1-0.5ug/ml
IHC-P: 0.5-1ug/ml (Antigen Retrieval: By Heat)
Direct ELISA: 0.1-0.5ug/ml

Tested Species: In-house tested species with positive results.

By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.

Other applications have not been tested. Optimal silutions should be determined by end users.

Enhanced Chemiluminescent Kit with anti-rabbit IgG (MBS176460) for western blot and HRP conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC-P.

Product References and Citations for anti-CPAMD8 antibody

1. Cheong, S.-S., Hentschel, L., Davidson, A. E., Gerrelli, D., Davie, R., Rizzo, R., Pontikos, N., Plagnol, V., Moore, A. T., Sowden, J. C., Michaelides, M., Snead, M., Tuft, S. J., Hardcastle, A. J. Mutations in CPAMD8 cause a unique form of autosomal-recessive anterior segment dysgenesis. Am. J. Hum. Genet. 99: 1338-1352, 2016. 2. Li, Z.-F., Wu, X., Engvall, E. Identification and characterization of CPAMD8, a novel member of the complement 3/alpha-2-macroglobulin family with a C-terminal Kazal domain. Genomics 83: 1083-1093, 2004.

Other Notes

Small volumes of anti-CPAMD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CPAMD8 purchase

MBS1751524 is an antibody targeting CPAMD8. Reactive in Human; No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CPAMD8. It may not necessarily be applicable to this product.

NCBI GI #
259016204
NCBI GeneID
27151
NCBI Accession #
Q8IZJ3.2
UniProt Primary Accession #
Q8IZJ3
UniProt Secondary Accession #
Q8NC09; Q9ULD7
UniProt Related Accession #
Q8IZJ3
NCBI Official Full Name
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
NCBI Official Synonym Full Names
C3 and PZP like, alpha-2-macroglobulin domain containing 8
NCBI Official Symbol
CPAMD8
NCBI Official Synonym Symbols
VIP; ASGD8; K-CAP
UniProt Protein Name
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
Protein Family
C3 and PZP-like alpha-2-macroglobulin domain-containing protein
UniProt Gene Name
CPAMD8
NCBI Protein Information
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8

NCBI Summary for CPAMD8

This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017]
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Research Articles on CPAMD8

1. study delineates a unique form of recessive anterior segment dysgeneses (ASD) and defines a role for CPAMD8, a protein of unknown function, in anterior segment development, implying another pathway for the pathogenicity of ASD

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-CPAMD8 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with CPAMD8 and Eye
 Brain Antibodies  >2 publications with CPAMD8 and Brain
 Bone Antibodies  >1 publications with CPAMD8 and Bone
 Embryonic Tissue Antibodies  >1 publications with CPAMD8 and Embryonic Tissue
 Kidney Antibodies  >1 publications with CPAMD8 and Kidney
 Uncharacterized Tissue Antibodies  >1 publications with CPAMD8 and Uncharacterized Tissue
 Testis Antibodies  >1 publications with CPAMD8 and Testis
 Muscle Antibodies  >1 publications with CPAMD8 and Muscle
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