Rabbit Anti-IL18 Polyclonal Antibody – Cat# MBS175182

Anti-mouse IL-18 antibody, MBS175182, Western blotting
Lane 1: Recombinant Mouse IL-18 Protein 10ng
Lane 2: Recombinant Mouse IL18 Protein 5ng
Lane 3: Recombinant Mouse IL18 Protein 2

IL18 Antibody – Rabbit Polyclonal

Name: IL18 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS175182
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175182

Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL18, Polyclonal Antibody

Full Product Name

Anti-mouse IL18 antibody

Product Gene Name

anti-IL18 antibody

Product Synonym Names

Interleukin-18; interleukin 18(interferon-gamma-inducing factor); Iboctadekin antibody; IFN gamma inducing factor antibody; IFN-gamma-inducing factor antibody; IGIF antibody; IL 1 gamma antibody; IL 18 antibody; IL 1g antibody; IL-1 gamma antibody; IL-18 antibody; IL1 gamma antibody; IL18 antibody; IL18 protein antibody; IL1F4 antibody; IL1g antibody; IL1gamma antibody; ILIF4 antibody; Interferon gamma inducing factor antibody; Interferon gamma-inducing factor antibody; Interleukin 1 gamma antibody; Interleukin 18 antibody; Interleukin-1 gamma antibody; Interleukin-18 antibody; Interleukin18 antibody; MGC12320 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

3D Structure

ModBase 3D Structure for P70380

Immunogen

E Coli-derived mouse IL-18 recombinant protein (Position: N36-S192).

Contents

Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Relevant Detection Systems

Please inquire.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-IL18 antibody

Western Blot (WB), Immunohistochemistry (IHC) - Paraffin embedded Section, ELISA (EIA)

Application Notes for anti-IL18 antibody

WB: Concentration: 0.1-0.5ug/ml
Species: Mouse
Antigen Retrieval: -

IHC - Paraffin: Concentration: 0.5-1ug/ml
Species: Mouse
Antigen Retrieval: By Heat

EIA: Concentration: 0.1-0.5ug/ml
Species: Mouse
Antigen Retrieval: -

By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20mins is required for the staining of formalin/paraffin sections.

Other applications have not been tested.
Optimal dilutions to be determined by end users.

Other Notes

Small volumes of anti-IL18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL18 purchase

MBS175182 is an antibody targeting IL18. Also known as Anti-mouse IL18 antibody. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL18. It may not necessarily be applicable to this product.

NCBI GI #

3219810

NCBI GeneID

16173

NCBI Accession #

P70380.2

UniProt Primary Accession #

P70380

UniProt Related Accession #

P70380

NCBI Official Full Name

Interleukin-18

NCBI Official Synonym Full Names

interleukin 18

NCBI Official Symbol

Il18

NCBI Official Synonym Symbols

Igif; Il-18

UniProt Protein Name

Interleukin-18

UniProt Synonym Protein Names

Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma

Protein Family

Interleukin

UniProt Gene Name

Il18

UniProt Synonym Gene Names

Igif; IL-18; IFN-gamma-inducing factor; IL-1 gamma

UniProt Entry Name

IL18_MOUSE

NCBI Protein Information

interleukin-18; IL-1 gamma; interleukin-1 gamma; IFN-gamma-inducing factor; interferon gamma-inducing factor; interferon-gamma-inducing factor

UniProt Comments for IL18

IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Cellular Component: extracellular space; apical plasma membrane; cytoplasm; extracellular region

Molecular Function: cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of smooth muscle cell migration; positive regulation of activated T cell proliferation; positive regulation of interleukin-8 production; positive regulation of superoxide release; positive regulation of neuron apoptosis; lipopolysaccharide-mediated signaling pathway; angiogenesis; inflammatory response; positive regulation of interleukin-17 production; regulation of cell adhesion; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of natural killer cell proliferation; T-helper 1 type immune response; MAPKKK cascade; interleukin-13 biosynthetic process; positive regulation of tumor necrosis factor production; sleep; positive regulation of chemokine production; positive regulation of vascular permeability; negative regulation of neutrophil apoptosis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of interferon-gamma production; induction of apoptosis via death domain receptors; response to hypoxia; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation

Research Articles on IL18

1. IL-18 expression is increased in murine vein grafts. Necrotic VSMCs promote monocytic inflammasome activation via an IL-1beta/IL-18-dependent pathway at the early stage of vein graft remodeling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL18 antibody

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Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Inflammatory Bowel Disease (IBD) Pathway antibodies	Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with anti-IL18 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1202 publications with IL18 and Inflammation
Necrosis Antibodies	>796 publications with IL18 and Necrosis
Cardiovascular Diseases Antibodies	>434 publications with IL18 and Cardiovascular Diseases
Lung Diseases Antibodies	>328 publications with IL18 and Lung Diseases
Kidney Diseases Antibodies	>306 publications with IL18 and Kidney Diseases
Hypersensitivity Antibodies	>266 publications with IL18 and Hypersensitivity
Liver Diseases Antibodies	>238 publications with IL18 and Liver Diseases
Arthritis, Rheumatoid Antibodies	>221 publications with IL18 and Arthritis, Rheumatoid
Heart Diseases Antibodies	>204 publications with IL18 and Heart Diseases
Hypersensitivity, Immediate Antibodies	>188 publications with IL18 and Hypersensitivity, Immediate

Organs/Tissues associated with anti-IL18 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>406 publications with IL18 and Liver
Spleen Antibodies	>284 publications with IL18 and Spleen
Brain Antibodies	>212 publications with IL18 and Brain
Skin Antibodies	>212 publications with IL18 and Skin
Intestine Antibodies	>156 publications with IL18 and Intestine
Stomach Antibodies	>40 publications with IL18 and Stomach
Embryonic Tissue Antibodies	>38 publications with IL18 and Embryonic Tissue
Eye Antibodies	>37 publications with IL18 and Eye
Thymus Antibodies	>29 publications with IL18 and Thymus
Ovary Antibodies	>27 publications with IL18 and Ovary