Mouse Anti-CAV1 Monoclonal Antibody – Cat# MBS1751920

Caveolin-1/CAV1 (CAV1) Antibody – Mouse Monoclonal

Name: CAV1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1751920
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1751920

Description: Mouse IgG monoclonal antibody for Caveolin-1/CAV1 detection. Tested with Tested with WB, IHC-P in Human.Background: CAV1 (Caveolin-1) is a protein that in humans is encoded by the CAV1 gene. The CAV1 gene is mapped to 7q31.2. The scaffolding… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Caveolin-1/CAV1, Monoclonal Antibody

Full Product Name

Anti-Caveolin-1/CAV1 Antibody (monoclonal, 12C7)

Product Gene Name

anti-CAV1 antibody

Product Synonym Names

Caveolin-1; CAV1; CAV; Caveolin 1, caveolae protein, 22kDa

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

12C7

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

Immunogen Affinity Purified

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -21 degree C for a longer time.
Avoid repeated freezing and thawing.

Molecular Weight

17,023 Da

3D Structure

ModBase 3D Structure for Q03135

Immunogen

E Coli-derived human Caveolin-1 recombinant protein (Position: G4-I178). Human Caveolin-1 shares 95% and 94% amino acid (aa) sequence identity with mouse and rat Caveolin-1, respectively.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Relevant Detection Systems

It is recommended to use an Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC-P.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CAV1 antibody

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Application Notes for anti-CAV1 antibody

WB: 0.1-0.5 mug/ml
IHC-P: 0.5-1 mug/ml
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.

Product References and Citations for anti-CAV1 antibody

1. Tahir, S. A., Yang, G., Ebara, S., Timme, T. L., Satoh, T., Li, L., Goltsov, A., Ittmann, M., Morrisett, J. D., Thompson, T. C.Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer.Cancer Res. 61: 3882-3885, 2001. 2. Wang, X. M., Zhang, Y., Kim, H. P., Zhou, Z., Feghali-Bostwick, C. A., Liu, F., Ifedigbo, E., Xu, X., Oury, T. D., Kaminski, N., Choi, A. M. K.Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.J. Exp. Med. 203: 2895-2906, 2006. 3. Yang, G., Truong, L. D., Timme, T. L., Ren, C., Wheeler, T. M., Park, S. H., Nasu, Y., Bangma, C. H., Kattan, M. W., Scardino, P. T., Thompson, T. C.Elevated expression of caveolin is associated with prostate and breast cancer.Clin. Cancer Res. 4: 1873-1880, 1998.

Other Notes

Small volumes of anti-CAV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAV1 purchase

MBS1751920 is an antibody targeting CAV1. Also known as Anti-Caveolin-1/CAV1 Antibody (monoclonal, 12C7). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CAV1. It may not necessarily be applicable to this product.

NCBI GI #

15451856

NCBI GeneID

857

NCBI Accession #

NP_001744.2

UniProt Primary Accession #

Q03135

UniProt Secondary Accession #

Q9UGP1; Q9UNG1; Q9UQH6

UniProt Related Accession #

Q03135

GenBank Nucleotide #

NM_001753.5

NCBI Official Full Name

caveolin-1 isoform alpha

NCBI Official Synonym Full Names

caveolin 1

NCBI Official Symbol

CAV1

NCBI Official Synonym Symbols

CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085

UniProt Protein Name

Caveolin-1

Protein Family

Caveolin

UniProt Gene Name

CAV1

UniProt Synonym Gene Names

CAV

NCBI Protein Information

caveolin-1

NCBI Summary for CAV1

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

UniProt Comments for CAV1

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).

Research Articles on CAV1

1. Study provides evidence that KIF13B and NPHP4 are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh-induced accumulation of SMO in the primary cilium as well as for activation of GLI-mediated target gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAV1 antibody

Reference Product	PubMed Publications
SRC antibody	>116 publications with CAV1 and SRC
CAV2 antibody	>110 publications with CAV1 and CAV2
NOS3 antibody	>64 publications with CAV1 and NOS3
EGFR antibody	>29 publications with CAV1 and EGFR
MAPK3 antibody	>27 publications with CAV1 and MAPK3
MAPK1 antibody	>26 publications with CAV1 and MAPK1
ABCB1 antibody	>24 publications with CAV1 and ABCB1
RHOA antibody	>24 publications with CAV1 and RHOA
FYN antibody	>21 publications with CAV1 and FYN
CSK antibody	>14 publications with CAV1 and CSK

Pathways associated with anti-CAV1 antibody

Products by Pathway	Pathway Diagram
ALK1 Signaling Events Pathway antibodies	ALK1 Signaling Events Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
Bacterial Invasion Of Epithelial Cells Pathway antibodies	Bacterial Invasion Of Epithelial Cells Pathway Diagram
Basigin Interactions Pathway antibodies	Basigin Interactions Pathway Diagram
Canonical Wnt Signaling Pathway antibodies	Canonical Wnt Signaling Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
EGFR1 Signaling Pathway antibodies	EGFR1 Signaling Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram

Diseases associated with anti-CAV1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>342 publications with CAV1 and Neoplasms
Cardiovascular Diseases Antibodies	>121 publications with CAV1 and Cardiovascular Diseases
Heart Diseases Antibodies	>73 publications with CAV1 and Heart Diseases
Breast Neoplasms Antibodies	>73 publications with CAV1 and Breast Neoplasms
Adenocarcinoma Antibodies	>59 publications with CAV1 and Adenocarcinoma
Neoplasm Metastasis Antibodies	>51 publications with CAV1 and Neoplasm Metastasis
Prostatic Neoplasms Antibodies	>47 publications with CAV1 and Prostatic Neoplasms
Inflammation Antibodies	>47 publications with CAV1 and Inflammation
Hypertension Antibodies	>42 publications with CAV1 and Hypertension
Fibrosis Antibodies	>40 publications with CAV1 and Fibrosis

Organs/Tissues associated with anti-CAV1 antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>374 publications with CAV1 and Muscle
Vascular Antibodies	>276 publications with CAV1 and Vascular
Heart Antibodies	>221 publications with CAV1 and Heart
Brain Antibodies	>193 publications with CAV1 and Brain
Blood Antibodies	>186 publications with CAV1 and Blood
Lung Antibodies	>133 publications with CAV1 and Lung
Kidney Antibodies	>108 publications with CAV1 and Kidney
Nerve Antibodies	>72 publications with CAV1 and Nerve
Prostate Antibodies	>67 publications with CAV1 and Prostate
Embryonic Tissue Antibodies	>61 publications with CAV1 and Embryonic Tissue