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WWOX Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752072

Description: Mouse IgG monoclonal antibody for WWOX detection. Tested with WB, IHC-P, FCM in Human; Mouse; Rat.Background: WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. This gene encodes a member of the… More details

$210 / 0.01 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
WWOX, Monoclonal Antibody
Full Product Name
Anti-WWOX Antibody (monoclonal, 3D10)
Product Gene Name
anti-WWOX antibody
Product Synonym Names
WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 4 degree C member 1; WWOX; FOR; SDR4 degree C1; WOX1; WW domain containing oxidoreductase
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3D10
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen Affinity Purified
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.
Avoid repeated freezing and thawing.
Molecular Weight
41,128 Da
3D Structure
ModBase 3D Structure for Q9NZC7
Immunogen
E Coli-derived human WWOX recombinant protein (Position: M1-D245).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Relevant Detection Systems
It is recommended to use an Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC-P.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-WWOX antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS)
Application Notes for anti-WWOX antibody
WB: 0.1-0.5 mug/ml
IHC-P: 0.5-1 mug/ml
FC/FACS: 1-3 mug/1x106 cells
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.

Product References and Citations for anti-WWOX antibody

1. "Entrez Gene: WWOX WW domain containing oxidoreductase". 2. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM (May 2000). "WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer". Cancer Res. 60 (8): 2140-5. 3. Mahajan NP, Whang YE, Mohler JL, Earp HS (November 2005). "Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.". Cancer Res. 65 (22): 10514-23.

Other Notes

Small volumes of anti-WWOX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WWOX purchase

MBS1752072 is an antibody targeting WWOX. Also known as Anti-WWOX Antibody (monoclonal, 3D10). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for WWOX. It may not necessarily be applicable to this product.

NCBI GI #
635172870
NCBI GeneID
51741
NCBI Accession #
NP_001278926.1
UniProt Primary Accession #
Q9NZC7
UniProt Secondary Accession #
Q5MYT5; Q96KM3; Q96RF2; Q9BTT8; Q9NPC9; Q9NRF4; Q9NRF5; Q9NRF6; Q9NRK1; Q9NZC5; A8K323
UniProt Related Accession #
Q9NZC7
GenBank Nucleotide #
NM_001291997.1
NCBI Official Full Name
WW domain-containing oxidoreductase isoform 4
NCBI Official Synonym Full Names
WW domain containing oxidoreductase
NCBI Official Symbol
WWOX
NCBI Official Synonym Symbols
FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E
UniProt Protein Name
WW domain-containing oxidoreductase
UniProt Synonym Protein Names
Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1
Protein Family
WW domain-containing oxidoreductase
UniProt Gene Name
WWOX
UniProt Synonym Gene Names
FOR; SDR41C1; WOX1
NCBI Protein Information
WW domain-containing oxidoreductase

NCBI Summary for WWOX

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
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UniProt Comments for WWOX

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
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Research Articles on WWOX

1. We have identified a variant in WWOX and in lncRNA RP11-679B19.1 as a diseasemodifying genetic variant associated with recurrent fibrostenotic CD

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-WWOX antibody

 Products by Pathway  Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By ERBB4 Pathway antibodies  Signaling By ERBB4 Pathway Diagram

Diseases associated with anti-WWOX antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >92 publications with WWOX and Carcinoma
 Breast Neoplasms Antibodies  >51 publications with WWOX and Breast Neoplasms
 Lung Neoplasms Antibodies  >30 publications with WWOX and Lung Neoplasms
 Chromosome Aberrations Antibodies  >28 publications with WWOX and Chromosome Aberrations
 Ovarian Neoplasms Antibodies  >26 publications with WWOX and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >21 publications with WWOX and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >19 publications with WWOX and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >18 publications with WWOX and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >18 publications with WWOX and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >17 publications with WWOX and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-WWOX antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >36 publications with WWOX and Lung
 Prostate Antibodies  >30 publications with WWOX and Prostate
 Brain Antibodies  >24 publications with WWOX and Brain
 Bone Antibodies  >22 publications with WWOX and Bone
 Liver Antibodies  >20 publications with WWOX and Liver
 Blood Antibodies  >16 publications with WWOX and Blood
 Lymph Antibodies  >10 publications with WWOX and Lymph
 Kidney Antibodies  >8 publications with WWOX and Kidney
 Ovary Antibodies  >8 publications with WWOX and Ovary
 Nerve Antibodies  >5 publications with WWOX and Nerve
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