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STIP1 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752225

Rabbit IgG Monoclonal antibody for P31948 detection. Tested positive for WB IHC IF/IF IP FC in Human Mouse Rat More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STIP1, Monoclonal Antibody
Full Product Name
Anti-STIP1 Monoclonal Antibody
Product Gene Name
anti-STIP1 antibody
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid, in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-Chromatography
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at 4 degree C short term. Store at -20 degree C long term
Avoid freeze/thaw cycles.
Molecular Weight
68,080 Da
3D Structure
ModBase 3D Structure for P31948
Immunogen
A synthesized peptide derived from human STIP1 Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-STIP1 antibody
Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-STIP1 antibody
WB: 1:1000-1:5000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:50
FC/FACS: 1:80

Western Blot (WB) of anti-STIP1 antibody

Figure 1. Western blot analysis of STIP1 using anti-STIP1 antibody (M02683).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-STIP1 antigen affinity purified polyclonal antibody at 0.5 ug/mL overnight at 4° C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-Rabbit IgG IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for STIP1.
Rabbit Anti-STIP1 Monoclonal Antibody – Cat# MBS1752225

Other Notes

Small volumes of anti-STIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STIP1 purchase

MBS1752225 is an antibody targeting STIP1. Also known as Anti-STIP1 Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STIP1. It may not necessarily be applicable to this product.

NCBI GI #
544063423
NCBI GeneID
10963
NCBI Accession #
NP_001269581.1
UniProt Primary Accession #
P31948
UniProt Secondary Accession #
Q3ZCU9; Q5TZU9; B4DM70; F5H0T1; G3XAD8
UniProt Related Accession #
P31948
GenBank Nucleotide #
NM_001282652.1
NCBI Official Full Name
stress-induced-phosphoprotein 1 isoform a
NCBI Official Synonym Full Names
stress induced phosphoprotein 1
NCBI Official Symbol
STIP1
NCBI Official Synonym Symbols
HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521
UniProt Protein Name
Stress-induced-phosphoprotein 1
UniProt Synonym Protein Names
Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521
Protein Family
STIP1 homology and U box-containing protein
UniProt Gene Name
STIP1
UniProt Synonym Gene Names
STI1; Hop
NCBI Protein Information
stress-induced-phosphoprotein 1

NCBI Summary for STIP1

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
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UniProt Comments for STIP1

Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 ().

Research Articles on STIP1

1. The G/G allele of stress induced phosphoprotein 1(STIP1) single nucleotide polymorphism rs4980524 is associated with the increased expression of STIP1 in endometriosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STIP1 antibody

 Reference Product  PubMed Publications
 DNAJB1 antibody  >6 publications with STIP1 and DNAJB1
 CDC37 antibody  >3 publications with STIP1 and CDC37
 PTGES3 antibody  >2 publications with STIP1 and PTGES3
 PRNP antibody  >2 publications with STIP1 and PRNP
 HSP90AA1 antibody  >2 publications with STIP1 and HSP90AA1
 WDR36 antibody  >1 publications with STIP1 and WDR36
 AHSA1 antibody  >1 publications with STIP1 and AHSA1

Pathways associated with anti-STIP1 antibody

 Products by Pathway  Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram

Diseases associated with anti-STIP1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with STIP1 and Inflammation
 Nervous System Diseases Antibodies  >8 publications with STIP1 and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with STIP1 and Brain Diseases
 Disease Models, Animal Antibodies  >3 publications with STIP1 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with STIP1 and Liver Diseases
 Necrosis Antibodies  >3 publications with STIP1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >2 publications with STIP1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with STIP1 and Liver Neoplasms
 Breast Neoplasms Antibodies  >2 publications with STIP1 and Breast Neoplasms
 Hypertension Antibodies  >1 publications with STIP1 and Hypertension

Organs/Tissues associated with anti-STIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with STIP1 and Brain
 Blood Antibodies  >17 publications with STIP1 and Blood
 Muscle Antibodies  >8 publications with STIP1 and Muscle
 Bone Antibodies  >6 publications with STIP1 and Bone
 Liver Antibodies  >6 publications with STIP1 and Liver
 Eye Antibodies  >5 publications with STIP1 and Eye
 Lung Antibodies  >5 publications with STIP1 and Lung
 Nerve Antibodies  >5 publications with STIP1 and Nerve
 Heart Antibodies  >4 publications with STIP1 and Heart
 Vascular Antibodies  >4 publications with STIP1 and Vascular
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