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CCR8 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752280

MBS1752280 is an antibody targeting CCR8. Also known as Anti-CCR8 Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. Anti-CCR8 Rabbit Monoclonal antibody (Cat# MBS1752280) More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCR8, Monoclonal Antibody
Full Product Name
Anti-CCR8 Monoclonal Antibody
Product Gene Name
anti-CCR8 antibody
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid; Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Purity/Purification
Affinity-chromatography
Concentration
Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. (lot specific)
Preparation and Storage
Store at -20 degree C for one year. For short term storage and frequent use, store at 4 degree C for up to one month. Avoid repeated freeze-thaw cycles.
3D Structure
ModBase 3D Structure for P51685
Immunogen
A synthesized peptide derived from human CCR8.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CCR8 antibody
Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB),
Application Notes for anti-CCR8 antibody
WB: 1:500~1:1000
ICC/IF: 1:50~1:200

Western Blot (WB) of anti-CCR8 antibody

Western blot analysis of CCR8 expression in Jurkat cell lysate
Rabbit Anti-CCR8 Monoclonal Antibody – Cat# MBS1752280

Immunofluorescence (IF) of anti-CCR8 antibody

Immunofluorescent analysis of HeLa cells, using CCR8 antibody
Rabbit Anti-CCR8 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS1752280

Western Blot (WB) of anti-CCR8 antibody

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
Rabbit Anti-CCR8 Monoclonal Antibody, Western Blot (WB) – Cat# MBS1752280

Western Blot (WB) of anti-CCR8 antibody

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
Rabbit Anti-CCR8 Monoclonal Antibody, Western Blot (WB) – Cat# MBS1752280

Western Blot (WB) of anti-CCR8 antibody

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.
Rabbit Anti-CCR8 Monoclonal Antibody, Western Blot (WB) – Cat# MBS1752280

Other Notes

Small volumes of anti-CCR8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCR8. It may not necessarily be applicable to this product.

NCBI GI #
4885121
NCBI GeneID
1237
NCBI Accession #
NP_005192.1
UniProt Primary Accession #
P51685
UniProt Secondary Accession #
Q3KNQ8; Q3KNR3; Q9BYX5; B2RC64
UniProt Related Accession #
P51685
GenBank Nucleotide #
NM_005201.3
NCBI Official Full Name
C-C chemokine receptor type 8
NCBI Official Synonym Full Names
C-C motif chemokine receptor 8
NCBI Official Symbol
CCR8
NCBI Official Synonym Symbols
CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8
UniProt Protein Name
C-C chemokine receptor type 8
UniProt Synonym Protein Names
CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1; CD_antigen: CDw198
Protein Family
C-C chemokine receptor
UniProt Gene Name
CCR8
UniProt Synonym Gene Names
CKRL1; CMKBR8; CMKBRL2; C-C CKR-8; CC-CKR-8; CCR-8; CKR-L1; GPRCY6
NCBI Protein Information
C-C chemokine receptor type 8

NCBI Summary for CCR8

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]
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UniProt Comments for CCR8

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.

Research Articles on CCR8

1. Authors demonstrate the pivotal role of CCR8(+) Treg cells in restraining immunity and highlight the potential clinical implications of this discovery.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCR8 antibody

 Reference Product  PubMed Publications
 CCL1 antibody  >81 publications with CCR8 and CCL1
 CCL17 antibody  >31 publications with CCR8 and CCL17
 CCL16 antibody  >8 publications with CCR8 and CCL16
 TPST2 antibody  >3 publications with CCR8 and TPST2

Pathways associated with anti-CCR8 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CCR8 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >96 publications with CCR8 and Immune System Diseases
 Neoplasms Antibodies  >23 publications with CCR8 and Neoplasms
 Lymphoma Antibodies  >16 publications with CCR8 and Lymphoma
 Lymphoma, Non-Hodgkin Antibodies  >12 publications with CCR8 and Lymphoma, Non-Hodgkin
 Eosinophilia Antibodies  >9 publications with CCR8 and Eosinophilia
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >6 publications with CCR8 and Encephalomyelitis, Autoimmune, Experimental
 Lymphoma, B-Cell Antibodies  >3 publications with CCR8 and Lymphoma, B-Cell
 Leukemia Antibodies  >3 publications with CCR8 and Leukemia
 Arteriosclerosis Antibodies  >3 publications with CCR8 and Arteriosclerosis
 Hodgkin Disease Antibodies  >2 publications with CCR8 and Hodgkin Disease

Organs/Tissues associated with anti-CCR8 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >167 publications with CCR8 and Blood
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