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p23 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752314

Rabbit IgG Monoclonal antibody for Q15185 detection. Tested positive for WB IF/IF IP in Human Mouse Rat More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
p23, Monoclonal Antibody
Full Product Name
Anti-p23 Monoclonal Antibody
Product Gene Name
anti-p23 antibody
Product Synonym Gene Name
PTGES3
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid, in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-Chromatography
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at 4 degree C short term. Store at -20 degree C long term
Avoid freeze/thaw cycles.
Molecular Weight
14,844 Da
3D Structure
ModBase 3D Structure for Q15185
Immunogen
A synthesized peptide derived from human p23 Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-p23 antibody
Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-p23 antibody
WB: 1:1000-1:5000
ICC/IF: 1:50-1:200
IP: 1:50

Western Blot (WB) of anti-p23 antibody

Figure 1. Western blot analysis of PTGES3 using anti-PTGES3 antibody (M04136).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-PTGES3 antigen affinity purified polyclonal antibody at 0.5 ug/mL overnight at 4° C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-Rabbit IgG IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for PTGES3.
Rabbit Anti-p23 Monoclonal Antibody – Cat# MBS1752314

Other Notes

Small volumes of anti-p23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for p23 purchase

MBS1752314 is an antibody targeting p23. Also known as Anti-p23 Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for p23. It may not necessarily be applicable to this product.

NCBI GI #
543583723
NCBI GeneID
10728
NCBI Accession #
NP_001269530.1
UniProt Primary Accession #
Q15185
UniProt Secondary Accession #
Q8WU70; A8K7D0; B4DHP2; B4DP11; B4DP21
UniProt Related Accession #
Q15185
GenBank Nucleotide #
NM_001282601.1
NCBI Official Full Name
prostaglandin E synthase 3 isoform b
NCBI Official Synonym Full Names
prostaglandin E synthase 3
NCBI Official Symbol
PTGES3
NCBI Official Synonym Symbols
P23; TEBP; cPGES
UniProt Protein Name
Prostaglandin E synthase 3
UniProt Synonym Protein Names
Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23
Protein Family
Protein
UniProt Gene Name
PTGES3
UniProt Synonym Gene Names
P23; TEBP; cPGES
NCBI Protein Information
prostaglandin E synthase 3

NCBI Summary for p23

This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]
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UniProt Comments for p23

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
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Research Articles on p23

1. The Hsp90 independence of the interaction between p23 and p53 DNA-binding domain, together with the competition of p23 versus DNA for p53, raises the intriguing possibility that p23, like other small charged proteins, may affect p53 in hitherto unknown ways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-p23 antibody

 Reference Product  PubMed Publications
 PTGS2 antibody  >8 publications with p23 and PTGS2
 PTGS1 antibody  >4 publications with p23 and PTGS1
 HSP90AA1 antibody  >3 publications with p23 and HSP90AA1
 STIP1 antibody  >2 publications with p23 and STIP1

Pathways associated with anti-p23 antibody

 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HSF1 Activation Pathway antibodies  HSF1 Activation Pathway Diagram

Diseases associated with anti-p23 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >2 publications with p23 and Lung Diseases
 Cardiomegaly Antibodies  >1 publications with p23 and Cardiomegaly
 Heart Diseases Antibodies  >1 publications with p23 and Heart Diseases
 Lung Neoplasms Antibodies  >1 publications with p23 and Lung Neoplasms
 Carcinoma Antibodies  >1 publications with p23 and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with p23 and Neoplasms, Experimental
 Immune System Diseases Antibodies  >1 publications with p23 and Immune System Diseases

Organs/Tissues associated with anti-p23 antibody

 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >3 publications with p23 and Uterus
 Lung Antibodies  >2 publications with p23 and Lung
 Vascular Antibodies  >1 publications with p23 and Vascular
 Ovary Antibodies  >1 publications with p23 and Ovary
 Heart Antibodies  >1 publications with p23 and Heart
 Muscle Antibodies  >1 publications with p23 and Muscle
 Embryonic Tissue Antibodies  >1 publications with p23 and Embryonic Tissue
 Brain Antibodies  >1 publications with p23 and Brain
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