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CD23 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752320

Rabbit IgG Monoclonal antibody for P06734 detection. Tested positive for WB IHC FC in Human More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD23, Monoclonal Antibody
Full Product Name
Anti-CD23 Monoclonal Antibody
Product Gene Name
anti-CD23 antibody
Product Synonym Gene Name
FCER2
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid, in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-Chromatography
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at 4 degree C short term. Store at -20 degree C long term
Avoid freeze/thaw cycles.
Molecular Weight
36,469 Da
3D Structure
ModBase 3D Structure for P06734
Immunogen
A synthesized peptide derived from human CD23 This receptor has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD23 antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-CD23 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
FC/FACS: 1:30

Western Blot (WB) of anti-CD23 antibody

Figure 1. Western blot analysis of FCER2 using anti-FCER2 antibody (M04237).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-FCER2 antigen affinity purified polyclonal antibody at 0.5 ug/mL overnight at 4° C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-Rabbit IgG IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for FCER2.
Rabbit Anti-CD23 Monoclonal Antibody – Cat# MBS1752320

Other Notes

Small volumes of anti-CD23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD23 purchase

MBS1752320 is an antibody targeting CD23. Also known as Anti-CD23 Monoclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD23. It may not necessarily be applicable to this product.

NCBI GI #
334085205
NCBI GeneID
2208
NCBI Accession #
NP_001193948.2
UniProt Primary Accession #
P06734
UniProt Related Accession #
P06734
GenBank Nucleotide #
NM_001207019.2
NCBI Official Full Name
low affinity immunoglobulin epsilon Fc receptor isoform b
NCBI Official Synonym Full Names
Fc fragment of IgE receptor II
NCBI Official Symbol
FCER2
NCBI Official Synonym Symbols
CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
UniProt Protein Name
Low affinity immunoglobulin epsilon Fc receptor
UniProt Synonym Protein Names
BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor; CD_antigen: CD23
Protein Family
Low affinity immunoglobulin epsilon Fc receptor
UniProt Gene Name
FCER2
UniProt Synonym Gene Names
CD23A; CLEC4J; FCE2; IGEBF
NCBI Protein Information
low affinity immunoglobulin epsilon Fc receptor

NCBI Summary for CD23

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
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UniProt Comments for CD23

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Research Articles on CD23

1. Data show that each IgE Fc is targeted by two single-domain antibodies (sdabs) having an epitope largely distinct from the FcepsilonRI binding site but overlapping significantly with the CD23-binding site.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD23 antibody

 Products by Pathway  Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 NOTCH2 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH2 Intracellular Domain Regulates Transcription Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By NOTCH Pathway antibodies  Signaling By NOTCH Pathway Diagram
 Signaling By NOTCH2 Pathway antibodies  Signaling By NOTCH2 Pathway Diagram

Diseases associated with anti-CD23 antibody

 Disease Name  Pubmed Publications
 Asthma Antibodies  >17 publications with CD23 and Asthma
 Lung Diseases Antibodies  >15 publications with CD23 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >14 publications with CD23 and Respiratory Hypersensitivity
 Hypersensitivity Antibodies  >14 publications with CD23 and Hypersensitivity
 Hypersensitivity, Immediate Antibodies  >14 publications with CD23 and Hypersensitivity, Immediate
 Inflammation Antibodies  >2 publications with CD23 and Inflammation
 Carcinoma Antibodies  >1 publications with CD23 and Carcinoma
 Intestinal Diseases Antibodies  >1 publications with CD23 and Intestinal Diseases
 Hyperplasia Antibodies  >1 publications with CD23 and Hyperplasia
 Bronchial Hyperreactivity Antibodies  >1 publications with CD23 and Bronchial Hyperreactivity

Organs/Tissues associated with anti-CD23 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with CD23 and Blood
 Lymph Node Antibodies  >1 publications with CD23 and Lymph Node
 Spleen Antibodies  >1 publications with CD23 and Spleen
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