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CRALBP Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752359

Rabbit IgG Monoclonal antibody for P12271 detection. Tested positive for WB IP in Mouse Rat More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CRALBP, Monoclonal Antibody
Full Product Name
Anti-CRALBP Monoclonal Antibody
Product Gene Name
anti-CRALBP antibody
Product Synonym Gene Name
RLBP1
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Liquid, in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-Chromatography
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at 4 degree C short term. Store at -20 degree C long term
Avoid freeze/thaw cycles.
Molecular Weight
36,474 Da
3D Structure
ModBase 3D Structure for P12271
Immunogen
A synthesized peptide derived from human CRALBP Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CRALBP antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-CRALBP antibody
WB: 1:500-1:2000
IP: 1:50

Western Blot (WB) of anti-CRALBP antibody

Figure 1. Western blot analysis of RLBP1 using anti-RLBP1 antibody (M05421).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-RLBP1 antigen affinity purified polyclonal antibody at 0.5 ug/mL overnight at 4° C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-Rabbit IgG IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for RLBP1.
Rabbit Anti-CRALBP Monoclonal Antibody – Cat# MBS1752359

Other Notes

Small volumes of anti-CRALBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRALBP purchase

MBS1752359 is an antibody targeting CRALBP. Also known as Anti-CRALBP Monoclonal Antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRALBP. It may not necessarily be applicable to this product.

NCBI GI #
4506541
NCBI GeneID
6017
NCBI Accession #
NP_000317.1
UniProt Primary Accession #
P12271
UniProt Secondary Accession #
B2R667
UniProt Related Accession #
P12271
GenBank Nucleotide #
NM_000326.5
NCBI Official Full Name
retinaldehyde-binding protein 1
NCBI Official Synonym Full Names
retinaldehyde binding protein 1
NCBI Official Symbol
RLBP1
NCBI Official Synonym Symbols
CRALBP
UniProt Protein Name
Retinaldehyde-binding protein 1
UniProt Synonym Protein Names
Cellular retinaldehyde-binding protein
UniProt Gene Name
RLBP1
UniProt Synonym Gene Names
CRALBP
NCBI Protein Information
retinaldehyde-binding protein 1

NCBI Summary for CRALBP

The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008]
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UniProt Comments for CRALBP

Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
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Research Articles on CRALBP

1. RLBP1 gene geographical area-related mutation is associated with retinitis punctata albescens.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRALBP antibody

 Reference Product  PubMed Publications
 RDH5 antibody  >7 publications with CRALBP and RDH5
 RPE65 antibody  >4 publications with CRALBP and RPE65
 RHO antibody  >2 publications with CRALBP and RHO
 RBP3 antibody  >1 publications with CRALBP and RBP3
 LRAT antibody  >1 publications with CRALBP and LRAT
 RDH8 antibody  >1 publications with CRALBP and RDH8

Pathways associated with anti-CRALBP antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Retinoid Cycle Disease Events Pathway antibodies  Retinoid Cycle Disease Events Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 The Retinoid Cycle In Cones (daylight Vision) Pathway antibodies  The Retinoid Cycle In Cones (daylight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
 The Visual Cycle I (vertebrates) Pathway antibodies  The Visual Cycle I (vertebrates) Pathway Diagram

Diseases associated with anti-CRALBP antibody

 Disease Name  Pubmed Publications
 Eye Diseases Antibodies  >31 publications with CRALBP and Eye Diseases
 Retinitis Pigmentosa Antibodies  >24 publications with CRALBP and Retinitis Pigmentosa
 Eye Diseases, Hereditary Antibodies  >20 publications with CRALBP and Eye Diseases, Hereditary
 Fundus Albipunctatus Antibodies  >7 publications with CRALBP and Fundus Albipunctatus
 Newfoundland Rod-Cone Dystrophy Antibodies  >2 publications with CRALBP and Newfoundland Rod-Cone Dystrophy
 Pain Antibodies  >1 publications with CRALBP and Pain
 Cardiovascular Diseases Antibodies  >1 publications with CRALBP and Cardiovascular Diseases
 Brain Diseases Antibodies  >1 publications with CRALBP and Brain Diseases
 Bothnia Retinal Dystrophy Antibodies  >1 publications with CRALBP and Bothnia Retinal Dystrophy

Organs/Tissues associated with anti-CRALBP antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >27 publications with CRALBP and Eye
 Brain Antibodies  >3 publications with CRALBP and Brain
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