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Li Cadherin (CDH17) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752378

Rabbit IgG Monoclonal antibody for Q12864 detection. Tested positive for WB IHC IP in Human More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LI Cadherin (CDH17), Monoclonal Antibody
Full Product Name
Anti-LI Cadherin Monoclonal Antibody
Product Gene Name
anti-CDH17 antibody
Clonality
Monoclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid, in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-Chromatography
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at 4 degree C short term. Store at -20 degree C long term
Avoid freeze/thaw cycles.
Molecular Weight
92,219 Da
3D Structure
ModBase 3D Structure for Q12864
Immunogen
A synthesized peptide derived from human LI-Cadherin Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CDH17 antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-CDH17 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IP: 1:50

Western Blot (WB) of anti-CDH17 antibody

Figure 1. Western blot analysis of CDH17 using anti-CDH17 antibody (M06389).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel)/90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CDH17 antigen affinity purified polyclonal antibody at 0.5 ug/mL overnight at 4° C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-Rabbit IgG IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for CDH17.
Rabbit Anti-CDH17 Monoclonal Antibody – Cat# MBS1752378

Other Notes

Small volumes of anti-CDH17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDH17 purchase

MBS1752378 is an antibody targeting CDH17. Also known as Anti-LI Cadherin Monoclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDH17. It may not necessarily be applicable to this product.

NCBI GI #
221316595
NCBI GeneID
1015
NCBI Accession #
NP_001138135.1
UniProt Primary Accession #
Q12864
UniProt Secondary Accession #
Q15336; Q2M2E0
UniProt Related Accession #
Q12864
GenBank Nucleotide #
NM_001144663.1
NCBI Official Full Name
cadherin-17
NCBI Official Synonym Full Names
cadherin 17
NCBI Official Symbol
CDH17
NCBI Official Synonym Symbols
HPT1; CDH16; HPT-1
UniProt Protein Name
Cadherin-17
UniProt Synonym Protein Names
Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin; LI-cadherin
Protein Family
Cadherin
UniProt Gene Name
CDH17
UniProt Synonym Gene Names
LI-cadherin
NCBI Protein Information
cadherin-17

NCBI Summary for CDH17

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
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UniProt Comments for CDH17

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
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Research Articles on CDH17

1. Data show that alteration in beta-catenin expression, a core component of the CDH17/beta-catenin axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1) serum levels in hepatocellular carcinoma (HCC) patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CDH17 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >51 publications with CDH17 and Neoplasms
 Carcinoma Antibodies  >40 publications with CDH17 and Carcinoma
 Liver Neoplasms Antibodies  >29 publications with CDH17 and Liver Neoplasms
 Stomach Neoplasms Antibodies  >28 publications with CDH17 and Stomach Neoplasms
 Liver Diseases Antibodies  >12 publications with CDH17 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >9 publications with CDH17 and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >5 publications with CDH17 and Lung Neoplasms
 Pancreatic Neoplasms Antibodies  >4 publications with CDH17 and Pancreatic Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with CDH17 and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >3 publications with CDH17 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-CDH17 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >49 publications with CDH17 and Intestine
 Liver Antibodies  >37 publications with CDH17 and Liver
 Stomach Antibodies  >29 publications with CDH17 and Stomach
 Blood Antibodies  >13 publications with CDH17 and Blood
 Ovary Antibodies  >2 publications with CDH17 and Ovary
 Embryonic Tissue Antibodies  >1 publications with CDH17 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with CDH17 and Pancreas
 Muscle Antibodies  >1 publications with CDH17 and Muscle
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