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FRZB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752503

Description: Rabbit IgG polyclonal antibody for FRZB detection. Tested with WB, Direct ELISA in Human; Mouse; Rat.Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FRZB, Polyclonal Antibody
Full Product Name
Anti-FRZB Antibody
Product Gene Name
anti-FRZB antibody
Product Synonym Names
Secreted frizzled-related protein 3; frizzled-related protein; Secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; Frizzled-related protein 1; FrzB-1; Frzb; Fiz; Fre; Frzb1; Sfrp3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen Affinity Purified
Specificity
No cross reactivity with other proteins.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for P97401
Immunogen
E Coli-derived mouse FRZB recombinant protein (Position: N49-K311).
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Relevant Detection Systems
We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500mug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-FRZB antibody
Western Blot (WB), Direct ELISA (EIA)
Application Notes for anti-FRZB antibody
WB: 0.1-0.5ug/ml
Direct ELISA: 0.1-0.5ug/ml

Product References and Citations for anti-FRZB antibody

1. Baker-Lepain JC, et al. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum, 2012 May. 2. Qin S, et al. FRZB knockdown upregulates beta-catenin activity and enhances cell aggressiveness in gastric cancer. Oncol Rep, 2014 May.  3. Wasmann RA, et al. Novel membrane frizzled-related protein gene mutation as cause of posterior microphthalmia resulting in high hyperopia with macular folds. Acta Ophthalmol, 2014 May.

Other Notes

Small volumes of anti-FRZB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRZB purchase

MBS1752503 is an antibody targeting FRZB. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FRZB. It may not necessarily be applicable to this product.

NCBI GI #
6755476
NCBI GeneID
20378
NCBI Accession #
NP_035486.1
UniProt Primary Accession #
P97401
UniProt Related Accession #
P97401
GenBank Nucleotide #
NP_035486.1
NCBI Official Full Name
secreted frizzled-related protein 3
NCBI Official Synonym Full Names
frizzled-related protein
NCBI Official Symbol
Frzb
NCBI Official Synonym Symbols
Frp; Sfrp3; fritz; frzb-1; frezzled
UniProt Protein Name
Secreted frizzled-related protein 3
UniProt Synonym Protein Names
Frezzled; Fritz; Frizzled-related protein 1; FrzB-1
Protein Family
Frizzy aggregation protein
UniProt Gene Name
Frzb
UniProt Synonym Gene Names
Fiz; Fre; Frzb1; Sfrp3; sFRP-3
UniProt Entry Name
SFRP3_MOUSE
NCBI Protein Information
secreted frizzled-related protein 3

UniProt Comments for FRZB

FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: Wnt-protein binding; protein binding

Biological Process: negative regulation of cell proliferation; convergent extension involved in organogenesis; inner ear morphogenesis; Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; multicellular organismal development; positive regulation of fat cell differentiation; negative regulation of cell growth; cell differentiation
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Research Articles on FRZB

1. Study identifies Sfrp3 as a mediator of the stromal-epithelial communication that is required for normal mouse mammary gland development. Loss of Sfrp3 in mice leads to an increase of ductal invasion and branching mirroring an early pregnancy state and predisposes for invasive breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FRZB antibody

 Reference Product  PubMed Publications
 Dkk1 antibody  >29 publications with FRZB and Dkk1
 Wnt3a antibody  >22 publications with FRZB and Wnt3a
 Wnt5a antibody  >12 publications with FRZB and Wnt5a
 Wnt8a antibody  >9 publications with FRZB and Wnt8a
 Wnt7a antibody  >7 publications with FRZB and Wnt7a
 Wnt8b antibody  >4 publications with FRZB and Wnt8b
 Met antibody  >2 publications with FRZB and Met
 Myf5 antibody  >1 publications with FRZB and Myf5
 Myod1 antibody  >1 publications with FRZB and Myod1

Pathways associated with anti-FRZB antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram

Diseases associated with anti-FRZB antibody

 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >51 publications with FRZB and Osteoarthritis
 Disease Models, Animal Antibodies  >14 publications with FRZB and Disease Models, Animal
 Adenocarcinoma Antibodies  >11 publications with FRZB and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >11 publications with FRZB and Cardiovascular Diseases
 Kidney Diseases Antibodies  >8 publications with FRZB and Kidney Diseases
 Breast Neoplasms Antibodies  >7 publications with FRZB and Breast Neoplasms
 Kidney Neoplasms Antibodies  >7 publications with FRZB and Kidney Neoplasms
 Lung Neoplasms Antibodies  >7 publications with FRZB and Lung Neoplasms
 Inflammation Antibodies  >6 publications with FRZB and Inflammation
 Abnormalities, Multiple Antibodies  >4 publications with FRZB and Abnormalities, Multiple

Organs/Tissues associated with anti-FRZB antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >44 publications with FRZB and Embryonic Tissue
 Eye Antibodies  >16 publications with FRZB and Eye
 Brain Antibodies  >15 publications with FRZB and Brain
 Kidney Antibodies  >14 publications with FRZB and Kidney
 Heart Antibodies  >11 publications with FRZB and Heart
 Lung Antibodies  >10 publications with FRZB and Lung
 Skin Antibodies  >7 publications with FRZB and Skin
 Stomach Antibodies  >7 publications with FRZB and Stomach
 Inner Ear Antibodies  >4 publications with FRZB and Inner Ear
 Dorsal Root Ganglion Antibodies  >3 publications with FRZB and Dorsal Root Ganglion
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