NALP2/NLRP2 Antibody – Rabbit Polyclonal

Description: Rabbit IgG polyclonal antibody for NALP2/NLRP2 detection. Tested with WB, Direct ELISA in Human; Mouse; Rat.

Background: NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene. It is mapped to 19q13.42. This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.

1. Kuchmiy, A. A., D'Hont, J., Hochepied, T., Lamkanfi, M. NLRP2 controls age-associated maternal fertility. J. Exp. Med. 213: 2851-2860, 2016. 2. Martinon, F., Hofmann, K., Tschopp, J. The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr. Biol. 10: R118-R120, 2001. 3. Peng, H., Chang, B., Lu, C., Su, J., Wu, Y., Lv, P., Wang, Y., Liu, J., Zhang, B., Quan, F., Guo, Z., Zhang, Y. Nlrp2, a maternal effect gene required for early embryonic development in the mouse. PLoS One 7: e30344, 2012.

Small volumes of anti-NALP2/NLRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1752514 is an antibody targeting NALP2/NLRP2. Reactive in Human, Mouse, Rat. Host: Rabbit.