Mouse Anti-HSPH1 Monoclonal Antibody – Cat# MBS1752816

Hsp105/HSPH1 (HSPH1) Antibody – Mouse Monoclonal

Name: HSPH1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1752816
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752816

Description: Mouse IgG monoclonal antibody for Hsp105/HSPH1 detection. Tested with WB, IHC-P, FCM in Human.Background: HSP105 (HEAT-SHOCK 105/110-KD PROTEIN 1), also called HSPH1 or HSP110, is a protein that in humans is encoded by the HSPH1 gene.… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hsp105/HSPH1, Monoclonal Antibody

Full Product Name

Anti-Hsp105/HSPH1 Antibody (Monoclonal, 3D10)

Product Gene Name

anti-HSPH1 antibody

Product Synonym Names

Heat shock protein 105 kDa; heat shock 105kDa/110kDa protein 1; Heat shock protein 105 kDa; Antigen NY-CO-25; Heat shock 110 kDa protein; HSPH1; HSP105; HSP110; KIAA0201

Clonality

Monoclonal

Isotype

IgG1

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Purity/Purification

Immunogen Affinity Purified

Specificity

No cross reactivity with other proteins.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

OMIM

610703

3D Structure

ModBase 3D Structure for Q92598

Immunogen

E Coli-derived human Hsp105 recombinant protein (Position: Y653-D858).

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Relevant Detection Systems

We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (MBS176460) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (MBS176453) for IHC(P).

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500mug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-HSPH1 antibody

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS)

Application Notes for anti-HSPH1 antibody

WB: 0.1-0.5ug/ml
IHC-P: 0.5-1ug/ml
FC/FACS: 1-3ug/1x106 cells

Product References and Citations for anti-HSPH1 antibody

1. Ishihara, K., Yasuda, K., Hatayama, T. Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105. Biochim. Biophys. Acta 1444: 138-142, 1999. 2. Dorard, C., de Thonel, A., Collura, A., Marisa, L., Svrcek, M., Lagrange, A., Jego, G., Wanherdrick, K., Joly, A. L., Buhard, O., Gobbo, J., Penard-Lacronique, V., and 16 others. Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis. Nature Med. 17: 1283-1289, 2011.

Other Notes

Small volumes of anti-HSPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPH1 purchase

MBS1752816 is an antibody targeting HSPH1. Also known as Anti-Hsp105/HSPH1 Antibody (Monoclonal, 3D10). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPH1. It may not necessarily be applicable to this product.

NCBI GI #

42544159

NCBI GeneID

10808

NCBI Accession #

NP_006635.2

UniProt Primary Accession #

Q92598

UniProt Related Accession #

Q92598

GenBank Nucleotide #

NP_006635.2

NCBI Official Full Name

heat shock protein 105 kDa isoform 1

NCBI Official Synonym Full Names

heat shock protein family H (Hsp110) member 1

NCBI Official Symbol

HSPH1

NCBI Official Synonym Symbols

HSP105; HSP105A; HSP105B; NY-CO-25

UniProt Protein Name

Heat shock protein 105 kDa

UniProt Synonym Protein Names

Antigen NY-CO-25; Heat shock 110 kDa protein

Protein Family

Heat shock protein

UniProt Gene Name

HSPH1

UniProt Synonym Gene Names

HSP105; HSP110; KIAA0201

UniProt Entry Name

HS105_HUMAN

NCBI Protein Information

heat shock protein 105 kDa

NCBI Summary for HSPH1

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

UniProt Comments for HSPH1

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; ATP binding; alpha-tubulin binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein

Research Articles on HSPH1

1. High HSP110 is associated with B-cell diffuse large B-cell lymphoma through regulating NF-kappaB signaling and MyD88 stabilization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSPH1 antibody

Reference Product	PubMed Publications
HSPA8 antibody	>4 publications with HSPH1 and HSPA8

Pathways associated with anti-HSPH1 antibody

Products by Pathway	Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-HSPH1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>15 publications with HSPH1 and Neoplasms
Adenocarcinoma Antibodies	>6 publications with HSPH1 and Adenocarcinoma
Disease Models, Animal Antibodies	>3 publications with HSPH1 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>2 publications with HSPH1 and Cardiovascular Diseases
Inflammation Antibodies	>2 publications with HSPH1 and Inflammation
Brain Diseases Antibodies	>2 publications with HSPH1 and Brain Diseases
Nervous System Diseases Antibodies	>2 publications with HSPH1 and Nervous System Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with HSPH1 and Cell Transformation, Neoplastic
Fibrosis Antibodies	>1 publications with HSPH1 and Fibrosis
Lung Neoplasms Antibodies	>1 publications with HSPH1 and Lung Neoplasms

Organs/Tissues associated with anti-HSPH1 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>6 publications with HSPH1 and Skin
Brain Antibodies	>6 publications with HSPH1 and Brain
Blood Antibodies	>5 publications with HSPH1 and Blood
Testis Antibodies	>3 publications with HSPH1 and Testis
Intestine Antibodies	>2 publications with HSPH1 and Intestine
Lung Antibodies	>2 publications with HSPH1 and Lung
Lymph Node Antibodies	>2 publications with HSPH1 and Lymph Node
Lymph Antibodies	>2 publications with HSPH1 and Lymph
Vascular Antibodies	>2 publications with HSPH1 and Vascular
Mouth Antibodies	>1 publications with HSPH1 and Mouth