BMAL1 Antibody – Rabbit Polyclonal

Description: Rabbit IgG polyclonal antibody for BMAL1/ARNTL detection. Tested with WB, Direct ELISA in Human; Mouse; Rat.

Background: Aryl hydrocarbon receptor nuclear translocator-like protein 1 is protein that in humans is encoded by the ARNTL gene. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

1. Hatanaka F, Matsubara C, Myung J, Yoritaka T, Kamimura N, Tsutsumi S, Kanai A, Suzuki Y, Sassone-Corsi P, Aburatani H, Sugano S,Takumi T (Dec 2010). "Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism". Molecular and Cellular Biology. 30 (24): 5636-5648. 2. Pappa KI, Gazouli M, Anastasiou E, Iliodromiti Z, Antsaklis A, Anagnou NP (Feb 2013). "The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus". Diabetes Research and Clinical Practice. 99 (2): 151-7. 3. Richards J, Diaz AN, Gumz ML (Oct 2014). "Clock genes in hypertension: novel insights from rodent models". Blood Pressure Monitoring. 19 (5): 249-54.

Small volumes of anti-BMAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1752828 is an antibody targeting BMAL1. Also known as Anti-BMAL1/ARNTL Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.