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FGF19 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175288

Description: Rabbit IgG polyclonal antibody for Fibroblast growth factor 19(FGF19) detection. Tested with WB, IHC-P in Human.Background: FGF19, Fibroblast growth factor 19, is a protein that in humans is encoded by the FGF19 gene. The protein encoded by this… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FGF19, Polyclonal Antibody
Full Product Name
Anti-FGF19 antibody
Product Gene Name
anti-FGF19 antibody
Product Synonym Names
Fibroblast growth factor 19(FGF-19); fibroblast growth factor 19; FGF 19 antibody; FGF-19 antibody; FGF15 antibody; FGF19 antibody; FGF19_HUMAN antibody; Fibroblast growth factor 15 antibody; Fibroblast growth factor 19 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
24,003 Da
OMIM
603891
3D Structure
ModBase 3D Structure for O95750
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human FGF19 (124-140aa EEIRPDGYNVYRSEKHR).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-FGF19 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-FGF19 antibody

Anti-FGF19 antibody, MBS175288, Western blotting
All lanes: Anti FGF19 (MBS175288) at 0.5ug/ml
Lane 1: U87 Whole Cell Lysate at 40ug
Lane 2: SMMC Whole Cell Lysate at 40ug
Predicted bind size: 24KD
Observed bind size: 24KD
Rabbit Anti-FGF19 Polyclonal Antibody – Cat# MBS175288

Immunohistochemistry (IHC) of anti-FGF19 antibody

Anti-FGF19 antibody, MBS175288, IHC(P)
IHC(P): Human Gallbladder Cancer Tissue
Rabbit Anti-FGF19 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175288

Other Notes

Small volumes of anti-FGF19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF19 purchase

MBS175288 is an antibody targeting FGF19. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF19. It may not necessarily be applicable to this product.

NCBI GI #
11132196
NCBI GeneID
9965
NCBI Accession #
O95750.1
UniProt Primary Accession #
O95750
UniProt Related Accession #
O95750
NCBI Official Full Name
Fibroblast growth factor 19
NCBI Official Synonym Full Names
fibroblast growth factor 19
NCBI Official Symbol
FGF19
UniProt Protein Name
Fibroblast growth factor 19
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF19
UniProt Synonym Gene Names
FGF-19
UniProt Entry Name
FGF19_HUMAN
NCBI Protein Information
fibroblast growth factor 19; FGF-19

NCBI Summary for FGF19

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
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UniProt Comments for FGF19

FGF19: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Belongs to the heparin-binding growth factors family.

Protein type: Cell development/differentiation; Secreted, signal peptide; Cytokine; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; positive regulation of glucose import; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; heart development; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; positive regulation of JNK cascade; positive regulation of protein amino acid phosphorylation; neural crest cell migration
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Research Articles on FGF19

1. FGF19 expression is not associated with lymph node metastasis and locally invasive characteristics of the tumor in colorectal cancers

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FGF19 antibody

 Reference Product  PubMed Publications
 FGFR4 antibody  >63 publications with FGF19 and FGFR4
 FGF23 antibody  >31 publications with FGF19 and FGF23
 KLB antibody  >24 publications with FGF19 and KLB
 FGF4 antibody  >19 publications with FGF19 and FGF4
 FGFR1 antibody  >16 publications with FGF19 and FGFR1
 FGFR3 antibody  >4 publications with FGF19 and FGFR3
 FGF18 antibody  >4 publications with FGF19 and FGF18
 FGF20 antibody  >2 publications with FGF19 and FGF20
 FGF16 antibody  >1 publications with FGF19 and FGF16

Pathways associated with anti-FGF19 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram

Diseases associated with anti-FGF19 antibody

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >36 publications with FGF19 and Liver Diseases
 Diarrhea Antibodies  >27 publications with FGF19 and Diarrhea
 Carcinoma, Hepatocellular Antibodies  >21 publications with FGF19 and Carcinoma, Hepatocellular
 Diabetes Mellitus, Type 2 Antibodies  >18 publications with FGF19 and Diabetes Mellitus, Type 2
 Fatty Liver Antibodies  >17 publications with FGF19 and Fatty Liver
 Cholestasis Antibodies  >11 publications with FGF19 and Cholestasis
 Inflammation Antibodies  >9 publications with FGF19 and Inflammation
 Kidney Diseases Antibodies  >8 publications with FGF19 and Kidney Diseases
 Skin Diseases Antibodies  >8 publications with FGF19 and Skin Diseases
 Neoplasms, Experimental Antibodies  >7 publications with FGF19 and Neoplasms, Experimental

Organs/Tissues associated with anti-FGF19 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >41 publications with FGF19 and Intestine
 Brain Antibodies  >17 publications with FGF19 and Brain
 Embryonic Tissue Antibodies  >9 publications with FGF19 and Embryonic Tissue
 Parathyroid Antibodies  >3 publications with FGF19 and Parathyroid
 Uterus Antibodies  >1 publications with FGF19 and Uterus
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