Mouse Anti-MVP Monoclonal Antibody – Cat# MBS1752894

MVP Antibody – Mouse Monoclonal

Name: MVP Antibody; Monoclonal; Mouse; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1752894
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752894

Description: Mouse IgG monoclonal antibody for MVP detection. Tested with WB, IHC-P, FCM in Human; Mouse; Rat.Background: Major vault protein is a protein that in humans is encoded by the MVP gene. This gene encodes the major component of the vault complex.… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MVP, Monoclonal Antibody

Full Product Name

Anti-MVP Antibody (Monoclonal, 8B12)

Product Gene Name

anti-MVP antibody

Product Synonym Names

Major vault protein; MVP; Lung resistance-related protein; MVP; LRP

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

8B12

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Form/Format

Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, store at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

OMIM

605088

3D Structure

ModBase 3D Structure for Q14764

Immunogen

E. coli-derived human MVP recombinant protein (Position: A2-H259).

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500mug/ml.

Relevant Detection Systems

MyBioSource recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (MBS176445) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (MBS176472) for IHC(P).

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-MVP antibody

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Flow Cytometry (FC/FACS)

Application Notes for anti-MVP antibody

WB: 0.1-0.5ug/mL
IHC-P: 0.5-1ug/mL
FC/FACS: 1-3 mug/1x106 cells
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested.

Product References and Citations for anti-MVP antibody

1. "Entrez Gene: MVP major vault protein". 2. Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (Jun 1996). "Major vault protein LRP-related multidrug resistance". European Journal of Cancer. 32A (6): 979-84.

Other Notes

Small volumes of anti-MVP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MVP purchase

MBS1752894 is an antibody targeting MVP. Also known as Anti-MVP Antibody (Monoclonal, 8B12). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MVP. It may not necessarily be applicable to this product.

NCBI GI #

19913412

NCBI GeneID

9961

NCBI Accession #

NP_005106.2

UniProt Primary Accession #

Q14764

UniProt Related Accession #

Q14764

GenBank Nucleotide #

NP_005106.2

NCBI Official Full Name

major vault protein isoform 1

NCBI Official Synonym Full Names

major vault protein

NCBI Official Symbol

MVP

NCBI Official Synonym Symbols

LRP; VAULT1

UniProt Protein Name

Major vault protein

UniProt Synonym Protein Names

Lung resistance-related protein

Protein Family

Hyperpolarization-activated voltage-gated potassium channel

UniProt Gene Name

MVP

UniProt Synonym Gene Names

LRP; MVP

UniProt Entry Name

MVP_HUMAN

NCBI Protein Information

major vault protein

NCBI Summary for MVP

This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

UniProt Comments for MVP

MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; protein phosphatase binding; protein kinase binding

Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation

Research Articles on MVP

1. Study shows that adipocytes induce major vault protein (MVP)-related multidrug-resistant phenotype in breast cancer cells, which could contribute to obesity-related chemoresistance. In a series of human breast tumors, a gradient of MVP expression was observed, and it was higher at the invasive front, where tumor cells are at close proximity to adipocytes, highlighting the clinical relevance of these results.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MVP antibody

Reference Product	PubMed Publications
ABCB1 antibody	>39 publications with MVP and ABCB1
ABCC1 antibody	>6 publications with MVP and ABCC1
PTEN antibody	>5 publications with MVP and PTEN
ABCC3 antibody	>4 publications with MVP and ABCC3
STAT1 antibody	>2 publications with MVP and STAT1
PTPN11 antibody	>1 publications with MVP and PTPN11
YPEL4 antibody	>1 publications with MVP and YPEL4

Diseases associated with anti-MVP antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>734 publications with MVP and Heart Diseases
Neoplasms Antibodies	>282 publications with MVP and Neoplasms
Drug Toxicity Antibodies	>77 publications with MVP and Drug Toxicity
Brain Diseases Antibodies	>74 publications with MVP and Brain Diseases
Neoplasm Metastasis Antibodies	>31 publications with MVP and Neoplasm Metastasis
Fibrosis Antibodies	>30 publications with MVP and Fibrosis
Hypertension Antibodies	>29 publications with MVP and Hypertension
Hypertrophy Antibodies	>29 publications with MVP and Hypertrophy
Disease Models, Animal Antibodies	>29 publications with MVP and Disease Models, Animal
Myocardial Infarction Antibodies	>26 publications with MVP and Myocardial Infarction

Organs/Tissues associated with anti-MVP antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>521 publications with MVP and Heart
Blood Antibodies	>253 publications with MVP and Blood
Lung Antibodies	>208 publications with MVP and Lung
Vascular Antibodies	>97 publications with MVP and Vascular
Brain Antibodies	>77 publications with MVP and Brain
Muscle Antibodies	>62 publications with MVP and Muscle
Bone Antibodies	>56 publications with MVP and Bone
Connective Tissue Antibodies	>42 publications with MVP and Connective Tissue
Liver Antibodies	>32 publications with MVP and Liver
Bladder Antibodies	>29 publications with MVP and Bladder