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CCR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752916

Description: Rabbit IgG polyclonal antibody for CCR2 detection. Tested with WB, IHC-P in Mouse; Rat.Background: C-C chemokine receptor type 2 (CCR2 or CD192 (cluster of differentiation 192) is a protein that in humans is encoded by the CCR2 gene. CCR2 is a… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CCR2, Polyclonal Antibody
Full Product Name
Anti-CCR2 Antibody
Product Gene Name
anti-Ccr2 antibody
Product Synonym Names
C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CC-CKR-2; CCR-2; CCR2; JE/FIC receptor; MCP-1 receptor; CD192; Ccr2; Cmkbr2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for P51683
Immunogen
A synthetic peptide corresponding to a sequence of mouse CCR2(RKHIAKRLCKQCPVFYRETADR).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-Ccr2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-Ccr2 antibody
WB: 0.25-0.5ug/ml (Mouse, Rat)
IHC-P (Embedded Section): 0.5-1ug/ml (Mouse, Rat)
Tested Species: In-house tested species with positive results.

Immunohistochemistry (IHC) of anti-Ccr2 antibody

Rabbit Anti-CCR2 Polyclonal Antibody – Cat# MBS1752916

Immunohistochemistry (IHC) of anti-Ccr2 antibody

Rabbit Anti-CCR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1752916

Western Blot (WB) of anti-Ccr2 antibody

Figure 1. Western blot analysis of Ccr2 using anti-Ccr2 antibody.
Rabbit Anti-CCR2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1752916

Product References and Citations for anti-Ccr2 antibody

1. Abbadie, C., Lindia, J. A., Cumiskey, A. M., Peterson, L. B., Mudgett, J. S., Bayne, E. K., DeMartino, J. A., MacIntyre, D. E., Forrest, M. J. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Nat. Acad. Sci. 100: 7947-7952, 2003.
2. Boring, L., Gosling, J., Cleary, M., Charo, I. F. Decreased lesion formation in CCR2 -/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394: 894-897, 1998.
3. Daugherty, B. L., Springer, M. S. The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. Genomics 41: 294-295, 1997.

Other Notes

Small volumes of anti-Ccr2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ccr2 purchase

MBS1752916 is an antibody targeting Ccr2. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Ccr2. It may not necessarily be applicable to this product.

NCBI GI #
6753466
NCBI GeneID
12772
NCBI Accession #
NP_034045.1
UniProt Primary Accession #
P51683
UniProt Related Accession #
P51683
GenBank Nucleotide #
NP_034045.1
NCBI Official Full Name
C-C chemokine receptor type 2
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 2
NCBI Official Symbol
Ccr2
NCBI Official Synonym Symbols
Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2
UniProt Protein Name
C-C chemokine receptor type 2
UniProt Synonym Protein Names
JE/FIC receptor; MCP-1 receptor; CD_antigen: CD192
Protein Family
C-C chemokine receptor
UniProt Gene Name
Ccr2
UniProt Synonym Gene Names
Cmkbr2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2
UniProt Entry Name
CCR2_MOUSE
NCBI Protein Information
C-C chemokine receptor type 2

UniProt Comments for Ccr2

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; protein binding; C-C chemokine receptor activity; cytokine binding; chemokine receptor activity

Biological Process: positive regulation of T-helper 1 type immune response; signal transduction; sensory perception of pain; chemotaxis; regulation of cell migration; monocyte chemotaxis; hemopoiesis; angiogenesis; cellular homeostasis; inflammatory response; healing during inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; humoral immune response; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; negative regulation of angiogenesis; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; negative regulation of eosinophil degranulation; positive regulation of T cell activation; positive regulation of T-helper 1 cell differentiation; apoptotic cell clearance; positive regulation of inflammatory response
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Research Articles on Ccr2

1. Radiotherapy (RT) upregulates CCL2 chemokine production in tumor cells, leading to a CCR2-dependent accumulation of tumor necrosis factor alpha (TNFalpha)-producing monocytes and CCR2(+) regulatory T cells (Treg). Cross-talk between innate and adaptive immune system components indicate CCL2/CCR2 and TNFalpha as potential clinical candidates to counterbalance the radioprotective action of monocyte-derived cells and Tregs.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Ccr2 antibody

 Products by Pathway  Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram

Diseases associated with anti-Ccr2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >866 publications with Ccr2 and Inflammation
 Immune System Diseases Antibodies  >557 publications with Ccr2 and Immune System Diseases
 Disease Models, Animal Antibodies  >380 publications with Ccr2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >343 publications with Ccr2 and Cardiovascular Diseases
 Necrosis Antibodies  >247 publications with Ccr2 and Necrosis
 Atherosclerosis Antibodies  >213 publications with Ccr2 and Atherosclerosis
 Lung Diseases Antibodies  >179 publications with Ccr2 and Lung Diseases
 Fibrosis Antibodies  >118 publications with Ccr2 and Fibrosis
 Kidney Diseases Antibodies  >108 publications with Ccr2 and Kidney Diseases
 Liver Diseases Antibodies  >100 publications with Ccr2 and Liver Diseases

Organs/Tissues associated with anti-Ccr2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >264 publications with Ccr2 and Bone Marrow
 Lung Antibodies  >244 publications with Ccr2 and Lung
 Lymph Node Antibodies  >112 publications with Ccr2 and Lymph Node
 Spleen Antibodies  >98 publications with Ccr2 and Spleen
 Skin Antibodies  >89 publications with Ccr2 and Skin
 Spinal Cord Antibodies  >69 publications with Ccr2 and Spinal Cord
 Adipose Tissue Antibodies  >65 publications with Ccr2 and Adipose Tissue
 Prostate Antibodies  >34 publications with Ccr2 and Prostate
 Uterus Antibodies  >25 publications with Ccr2 and Uterus
 Pancreas Antibodies  >24 publications with Ccr2 and Pancreas
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