Rabbit Anti-PTPN22 Polyclonal Antibody – Cat# MBS1752941

Figure 1. Western blot analysis of PTPN22 using anti-PTPN22 antibody.

PTPN22 Antibody – Rabbit Polyclonal

Name: PTPN22 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1752941
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752941

Description: Rabbit IgG polyclonal antibody for PTPN22 detection. Tested with WB, Direct ELISA in Human; Mouse; Rat.Background: Protein tyrosine phosphatase, non-receptor type 22 (lymphoid), also known as PTPN22, is a protein that in humans is encoded by the… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PTPN22, Polyclonal Antibody

Full Product Name

Anti-PTPN22 Antibody

Product Gene Name

anti-PTPN22 antibody

Product Synonym Names

Tyrosine-protein phosphatase non-receptor type 22; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase; PEP; PTPN22; PTPN8

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen affinity purified.

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.

OMIM

152700

3D Structure

ModBase 3D Structure for Q9Y2R2

Immunogen

E Coli-derived human PTPN22 recombinant protein (Position: E207-T652).

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-PTPN22 antibody

Western Blot (WB), Direct ELISA (EIA)

Application Notes for anti-PTPN22 antibody

WB: 0.25-0.5ug/ml (Human, Mouse, Rat)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-PTPN22 antibody

1. Kallberg, H., Padyukov, L., Plenge, R. M., Ronnelid, J., Gregersen, P. K., van der Helm-van Mil, A. H. M., Toes, R. E. M., Huizinga, T. W., Klareskog, L., Alfredsson, L. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am. J. Hum. Genet. 80: 867-875, 2007.
2. Kawasaki, E., Awata, T., Ikegami, H., Kobayashi, T., Maruyama, T., Nakanishi, K., Shimada, A., Uga, M., Kurihara, S., Kawabata, Y., Tanaka, S., Kanazawa, Y., Lee, I., Eguchi, K., Japanese Study Group on Type 1 Diabetes Genetics. Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations. Am. J. Med. Genet. 140A: 586-593, 2006. Note: Erratum: Am. J. Med. Genet. 143A: 1812-1813, 2007.
3. Kyogoku, C., Langefeld, C. D., Ortmann, W. A., Lee, A., Selby, S., Carlton, V. E. H., Chang, M., Ramos, P., Baechler, E. C., Batliwalla, F. M., Novitzke, J., Williams, A. H., and 10 others. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am. J. Hum. Genet. 75: 504-507, 2004.

Other Notes

Small volumes of anti-PTPN22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPN22 purchase

MBS1752941 is an antibody targeting PTPN22. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN22. It may not necessarily be applicable to this product.

NCBI GI #

301171669

NCBI GeneID

26191

NCBI Accession #

NP_001180360.1

UniProt Primary Accession #

Q9Y2R2

UniProt Related Accession #

Q9Y2R2

GenBank Nucleotide #

NP_001180360.1

NCBI Official Full Name

tyrosine-protein phosphatase non-receptor type 22 isoform 3

NCBI Official Synonym Full Names

protein tyrosine phosphatase non-receptor type 22

NCBI Official Symbol

PTPN22

NCBI Official Synonym Symbols

LYP; PEP; LYP1; LYP2; PTPN8; PTPN22.5; PTPN22.6

UniProt Protein Name

Tyrosine-protein phosphatase non-receptor type 22

UniProt Synonym Protein Names

Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase

Protein Family

Tyrosine-protein phosphatase non-receptor

UniProt Gene Name

PTPN22

UniProt Synonym Gene Names

PTPN8; LyP; PEP

UniProt Entry Name

PTN22_HUMAN

NCBI Protein Information

tyrosine-protein phosphatase non-receptor type 22

NCBI Summary for PTPN22

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

UniProt Comments for PTPN22

PTPN22: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity; kinase binding; SH3 domain binding

Biological Process: regulation of B cell receptor signaling pathway; regulation of natural killer cell proliferation; negative regulation of T cell receptor signaling pathway; protein amino acid dephosphorylation; negative regulation of T cell activation; T cell differentiation; regulation of innate immune response

Disease: Diabetes Mellitus, Insulin-dependent; Systemic Lupus Erythematosus; Rheumatoid Arthritis

Research Articles on PTPN22

1. Results showed that 1858 C/T PTPN22 SNP significantly associated with rheumatoid arthritis (RA). The 1858T allele frequency was also significantly increased in RA patients in comparison to the controls. Data demonstrated a significant reduction of IL-4 and IL-10 in PTPN22 1858C/T compared to 1858C/C RA patients. In addition, upregulation of IL-6, IFN-gamma, and TNF-alpha was observed in PTPN22 1858C/T vs. 1858C/C RA pa...

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPN22 antibody

Reference Product	PubMed Publications
CSK antibody	>12 publications with PTPN22 and CSK
LCK antibody	>5 publications with PTPN22 and LCK
GRB2 antibody	>4 publications with PTPN22 and GRB2
CBL antibody	>2 publications with PTPN22 and CBL
ZAP70 antibody	>1 publications with PTPN22 and ZAP70
CD247 antibody	>1 publications with PTPN22 and CD247

Diseases associated with anti-PTPN22 antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>440 publications with PTPN22 and Immune System Diseases
Arthritis, Rheumatoid Antibodies	>256 publications with PTPN22 and Arthritis, Rheumatoid
Diabetes Mellitus, Type 1 Antibodies	>127 publications with PTPN22 and Diabetes Mellitus, Type 1
Lupus Erythematosus, Systemic Antibodies	>85 publications with PTPN22 and Lupus Erythematosus, Systemic
Inflammation Antibodies	>36 publications with PTPN22 and Inflammation
Inflammatory Bowel Diseases Antibodies	>24 publications with PTPN22 and Inflammatory Bowel Diseases
Necrosis Antibodies	>21 publications with PTPN22 and Necrosis
Vasculitis Antibodies	>16 publications with PTPN22 and Vasculitis
Lung Diseases Antibodies	>11 publications with PTPN22 and Lung Diseases
Neoplasms Antibodies	>11 publications with PTPN22 and Neoplasms

Organs/Tissues associated with anti-PTPN22 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>158 publications with PTPN22 and Blood
Thyroid Antibodies	>56 publications with PTPN22 and Thyroid
Skin Antibodies	>18 publications with PTPN22 and Skin
Pancreas Antibodies	>16 publications with PTPN22 and Pancreas
Thymus Antibodies	>11 publications with PTPN22 and Thymus
Bone Marrow Antibodies	>7 publications with PTPN22 and Bone Marrow
Connective Tissue Antibodies	>5 publications with PTPN22 and Connective Tissue
Muscle Antibodies	>4 publications with PTPN22 and Muscle
Lymph Node Antibodies	>3 publications with PTPN22 and Lymph Node
Brain Antibodies	>3 publications with PTPN22 and Brain