Rabbit Anti-CDKN1C Polyclonal Antibody – Cat# MBS1752974

P57 Kip2/CDKN1C (CDKN1C) Antibody – Rabbit Polyclonal

Name: CDKN1C Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1752974
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752974

Description: Rabbit IgG polyclonal antibody for p57 Kip2/CDKN1C detection. Tested with WB in Human.Background: Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. It is… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

p57 Kip2/CDKN1C, Polyclonal Antibody

Full Product Name

Anti-p57 Kip2/CDKN1C Antibody

Product Gene Name

anti-CDKN1C antibody

Product Synonym Names

Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2; CDKN1C; KIP2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen affinity purified.

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.

OMIM

130650

3D Structure

ModBase 3D Structure for P49918

Immunogen

A synthetic peptide corresponding to a sequence of human p57 Kip2/CDKN1C(AAIKKLSGPLISDFFAKRKR).

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CDKN1C antibody

Western blot (WB)

Application Notes for anti-CDKN1C antibody

WB: 0.1-0.25ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-CDKN1C antibody

1. Algar, E., Brickell, S., Deeble, G., Amor, D., Smith, P. Analysis of CDKN1C in Beckwith Wiedemann syndrome. Hum. Mutat. 15: 497-508, 2000.
2. Algar, E. M., Deeble, G. J., Smith, P. J. CDKN1C expression in Beckwith-Wiedemann syndrome patients with allele imbalance. J. Med. Genet. 36: 524-531, 1999.
3. Arboleda, V. A., Lee, H., Parnaik, R., Fleming, A., Banerjee, A., Ferraz-de-Souza, B., Delot, E. C., Rodriguez-Fernandez, I. A., Braslavsky, D., Bergada, I., Dell'Angelica, E. C., Nelson, S. F., Martinez-Agosto, J. A., Achermann, J. C., Vilain, E. Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome. Nature Genet. 44: 788-792, 2012.

Other Notes

Small volumes of anti-CDKN1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDKN1C purchase

MBS1752974 is an antibody targeting CDKN1C. Also known as Anti-p57 Kip2/CDKN1C Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKN1C. It may not necessarily be applicable to this product.

NCBI GI #

4557441

NCBI GeneID

1028

NCBI Accession #

NP_000067.1

UniProt Primary Accession #

P49918

UniProt Related Accession #

P49918

GenBank Nucleotide #

NP_000067.1

NCBI Official Full Name

cyclin-dependent kinase inhibitor 1C isoform a

NCBI Official Synonym Full Names

cyclin dependent kinase inhibitor 1C

NCBI Official Symbol

CDKN1C

NCBI Official Synonym Symbols

BWS; WBS; p57; BWCR; KIP2; p57Kip2

UniProt Protein Name

Cyclin-dependent kinase inhibitor 1C

UniProt Synonym Protein Names

Cyclin-dependent kinase inhibitor p57; p57Kip2

Protein Family

Cyclin-dependent kinase inhibitor

UniProt Gene Name

CDKN1C

UniProt Synonym Gene Names

KIP2

UniProt Entry Name

CDN1C_HUMAN

NCBI Protein Information

cyclin-dependent kinase inhibitor 1C

NCBI Summary for CDKN1C

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

UniProt Comments for CDKN1C

p57Kip2: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding

Biological Process: negative regulation of kinase activity; camera-type eye development; adrenal gland development; multicellular organism growth; positive regulation of transcription, DNA-dependent; regulation of mitotic cell cycle; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; uterus development; neuron maturation; negative regulation of phosphorylation; myeloid cell differentiation; cell cycle arrest; negative regulation of transcription, DNA-dependent; kidney development; skeletal development; aging; negative regulation of epithelial cell proliferation

Disease: Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies; Beckwith-wiedemann Syndrome

Research Articles on CDKN1C

1. Rare clinical findings in three sporadic cases of Beckwith-Wiedemann syndrome due to novel mutations in the CDKN1C gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CDKN1C antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>196 publications with CDKN1C and Neoplasms
Beckwith-Wiedemann Syndrome Antibodies	>107 publications with CDKN1C and Beckwith-Wiedemann Syndrome
Adenocarcinoma Antibodies	>29 publications with CDKN1C and Adenocarcinoma
Kidney Diseases Antibodies	>26 publications with CDKN1C and Kidney Diseases
Hyperplasia Antibodies	>20 publications with CDKN1C and Hyperplasia
Liver Neoplasms Antibodies	>16 publications with CDKN1C and Liver Neoplasms
Liver Diseases Antibodies	>15 publications with CDKN1C and Liver Diseases
Disease Models, Animal Antibodies	>14 publications with CDKN1C and Disease Models, Animal
Breast Neoplasms Antibodies	>14 publications with CDKN1C and Breast Neoplasms
Carcinoma, Hepatocellular Antibodies	>13 publications with CDKN1C and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-CDKN1C antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>59 publications with CDKN1C and Embryonic Tissue
Placenta Antibodies	>50 publications with CDKN1C and Placenta
Muscle Antibodies	>44 publications with CDKN1C and Muscle
Kidney Antibodies	>43 publications with CDKN1C and Kidney
Blood Antibodies	>41 publications with CDKN1C and Blood
Eye Antibodies	>27 publications with CDKN1C and Eye
Brain Antibodies	>24 publications with CDKN1C and Brain
Liver Antibodies	>24 publications with CDKN1C and Liver
Skin Antibodies	>20 publications with CDKN1C and Skin
Heart Antibodies	>17 publications with CDKN1C and Heart