Melanoma Gp100/Pmel (PMEL) Antibody – Rabbit Polyclonal

Description: Rabbit IgG polyclonal antibody for Melanoma gp100/Pmel detection. Tested with WB, Direct ELISA in Mouse; Rat.

Background: Melanocyte protein PMEL also known as premelanosome protein (PMEL) or silver locus protein homolog (SILV) is a protein that in humans is encoded by the PMEL gene. It is mapped to 10 D3; 10 77.13 cM. This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.

1. Kubota, R., Wang, Y., Minoshima, S., Kudoh, J., Mashima, Y., Oguchi, Y., Shimizu, N. Mapping of the human gene for a melanocyte protein panel Pmel 17 (D12S53E) to chromosome 12q13-q14. Genomics 26: 430-431, 1995.
2. Kwon, B. S., Chintamaneni, C., Kozak, C. A., Copeland, N. G., Gilbert, D. J., Jenkins, N., Barton, D., Francke, U., Kobayashi, Y., Kim, K. K. A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12. Proc. Nat. Acad. Sci. 88: 9228-9232, 1991.
3. Kwon, B. S., Halaban, R., Ponnazhagan, S., Kim, K., Chintamaneni, C., Bennett, D., Pickard, R. T. Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Res. 23: 154-158, 1995.

Small volumes of anti-Pmel antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1752978 is an antibody targeting Pmel. Also known as Anti-Melanoma gp100/Pmel Antibody. Reactive in Mouse, Rat. Host: Rabbit.