ME2 Antibody – Rabbit Polyclonal

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

ME2: a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

Protein type: Oxidoreductase; EC 1.1.1.38; Mitochondrial; Carbohydrate Metabolism - pyruvate

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: intracellular membrane-bound organelle; mitochondrion; mitochondrial matrix

Molecular Function: malate dehydrogenase (decarboxylating) activity; electron carrier activity; metal ion binding; NAD binding; oxaloacetate decarboxylase activity

Biological Process: malate metabolic process

Disease: Opioid Dependence, Susceptibility To, 1; Epilepsy, Idiopathic Generalized